MRI for prostate cancer: can computed high b-value DWI replace native acquisitions?



To compare computed high b-value diffusion-weighted images (c-DWI) derived from low b-value DWI images and acquired high b-value DWI (a-DWI), in overall image quality and prostate cancer detection rate.

Materials and methods

A total of 124 consecutive men with suspected prostate cancer (PCa) underwent diagnosis prostate MRI on a 3.0 T MR system using a 32-channel phased-array torso coil. Among them, 63 underwent prostate biopsy. MRI protocol included 3DT2w images, high resolution Fov Optimized and Constrained Undistorted Single-Shot (FOCUS™) DWI images with b-values of 100, 400, 800, and 2000 s/mm2 and dynamic contrast enhanced images. C-DWI images (2000 and 2500 s/mm2) were derived from the three lower acquired b-value DWI images using a mono-exponential diffusion decay. C-DWI and acquired high b-value DWI (a-DWI) (2000 s/mm2) were compared for image quality (background signal suppression, anatomic clarity, ghosting, distortion) and tumor conspicuity by four radiologists.


C-DWIs demonstrated higher rating than a-DWIs for overall image quality despite worsened ghosting. In patients with a biopsy, similar detection rate was observed while conspicuity was better with c-DWI (p < 0.001). Non-acquisition of high b-value a-DWI reduced total acquisition time by 220 s per patient.


C-DWI provides a substantial reduction in acquisition time while maintaining comparable prostate cancer detection rate and improving global image quality.

Key Points

• Computed DWI improves global quality of prostate MRI.

• Computed DWI improves analysis of DWI images with decrease acquisition time.

• Computed DWI provides greater background suppression of parenchyma and improves conspicuity of suspicious lesion.

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Fig. 1
Fig. 2



Acquired b 2000 images


Acquired diffusion-weighted images


Apparent diffusion coefficient


Area under the receiver operating curves


Computed b 2000 images


Computed b 2500 images


Computed diffusion-weighted images


Dynamic contrast-enhanced


Digital rectal examination


Diffusion-weighted imaging


Interquartile range


Multiparametric magnetic-resonance imaging




Prostate biopsy


Prostate cancer


Prostate serum antigen


Peripheral zone


Region of interest


Standard biopsy


Signal-to-noise ratio (SNR)




Targeted biopsy


Transrectal ultrasonographic


Transitional zone




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Correspondence to Raphaele Renard-Penna.

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The scientific guarantor of this publication is Dr Raphaele Renard-Penna.

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The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

One of the authors has significant statistical expertise.

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Written informed consent was obtained from all subjects (patients) in this study.

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Institutional Review Board approval was obtained.


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Jendoubi, S., Wagner, M., Montagne, S. et al. MRI for prostate cancer: can computed high b-value DWI replace native acquisitions?. Eur Radiol 29, 5197–5204 (2019).

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  • Prostatic neoplasms
  • Diagnostic imaging
  • Magnetic resonance imaging
  • Diffusion-weighted MRI