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Radial MP2RAGE sequence for rapid 3D T1 mapping of mouse abdomen: application to hepatic metastases

  • Thibaut L. Faller
  • Aurélien J. Trotier
  • Sylvain Miraux
  • Emeline J. RibotEmail author
Magnetic Resonance
  • 76 Downloads

Abstract

Objectives

The T1 longitudinal recovery time is regarded as a biomarker of cancer treatment efficiency. In this scope, the Magnetization Prepared 2 RApid Gradient Echo (MP2RAGE) sequence relevantly complies with fast 3D T1 mapping. Nevertheless, with its Cartesian encoding scheme, it is very sensitive to respiratory motion. Consequently, a radial encoding scheme was implemented for the detection and T1 measurement of hepatic metastases in mice at 7T.

Methods

A 3D radial encoding scheme was developed using a golden angle distribution for the k-space trajectories. As in that case, each projection contributes to the image contrast, the signal equations had to be modified. Phantoms containing increasing gadoteridol concentrations were used to determine the accuracy of the sequence in vitro. Healthy mice were repetitively scanned to assess the reproducibility of the T1 values. The growth of hepatic metastases was monitored. Undersampling robustness was also evaluated.

Results

The accuracy of the T1 values obtained with the radial MP2RAGE sequence was > 90% compared to the Inversion-Recovery sequence. The motion robustness of this new sequence also enabled repeatable T1 measurements on abdominal organs. Hepatic metastases of less than 1-mm diameter were easily detected and T1 heterogeneities within the metastasis and between the metastases within the same animal were measured. With a twofold acceleration factor using undersampling, high-quality 3D T1 abdominal maps were achieved in 9 min.

Conclusions

The radial MP2RAGE sequence could be used for fast 3D T1 mapping, to detect and characterize metastases in regions subjected to respiratory motion.

Key Points

• The Cartesian encoding of the MP2RAGE sequence was modified to a radial encoding. The modified sequence enabled accurate T 1 measurements on phantoms and on abdominal organs of mice.

• Hepatic metastases were easily detected due to high contrast. Heterogeneity in T 1 was measured within the metastases and between each metastasis within the same animal.

• As implementation of this sequence does not require specific hardware, we expect that it could be readily available for clinical practice in humans.

Keywords

Magnetic resonance imaging Mice Three-dimensional imaging Liver Metastasis 

Abbreviations

bSSFP

Balanced steady-state free precession

MP2RAGE

Magnetization Prepared 2 RApid Gradient Echoes

Notes

Funding

This study has received funding by the Laboratory of Excellence TRAIL ANR-10-LABX-57.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Emeline J Ribot.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Ethical approval

Approval from the Animal Care and Use Institutional ethics committee of Bordeaux was obtained.

Methodology

• prospective

• experimental

• performed at one institution

Supplementary material

330_2019_6081_MOESM1_ESM.docx (1.3 mb)
ESM 1 (DOCX 1295 kb)

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Copyright information

© European Society of Radiology 2019

Authors and Affiliations

  • Thibaut L. Faller
    • 1
  • Aurélien J. Trotier
    • 1
  • Sylvain Miraux
    • 1
  • Emeline J. Ribot
    • 1
    Email author
  1. 1.Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536CNRS/University BordeauxBordeauxFrance

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