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Radiomics on multi-modalities MR sequences can subtype patients with non-metastatic nasopharyngeal carcinoma (NPC) into distinct survival subgroups

  • En-Hong Zhuo
  • Wei-Jing Zhang
  • Hao-Jiang Li
  • Guo-Yi Zhang
  • Bing-Zhong Jing
  • Jian Zhou
  • Chun-Yan Cui
  • Ming-Yuan Chen
  • Ying Sun
  • Li-Zhi LiuEmail author
  • Hong-Min CaiEmail author
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Abstract

Objectives

To explore and evaluate the feasibility of radiomics in stratifying nasopharyngeal carcinoma (NPC) into distinct survival subgroups through multi-modalities MRI.

Methods

A total of 658 patients (training cohort: 424; validation cohort: 234) with non-metastatic NPC were enrolled in the retrospective analysis. Each slice was considered as a sample and 4863 radiomics features on the tumor region were extracted from T1-weighted, T2-weighted, and contrast-enhanced T1-weighted MRI. Consensus clustering and manual aggregation were performed on the training cohort to generate a baseline model and classification reference used to train a support vector machine classifier. The risk of each patient was defined as the maximum risk among the slices. Each patient in the validation cohort was assigned to the risk model using the trained classifier. Harrell’s concordance index (C-index) was used to measure the prognosis performance, and differences between subgroups were compared using the log-rank test.

Results

The training cohort was clustered into four groups with distinct survival patterns. Each patient was assigned to one of the four groups according to the estimated risk. Our method gave a performance (C-index = 0.827, p < .004 and C-index = 0.814, p < .002) better than the T-stage (C-index = 0.815, p = .002 and C-index = 0.803, p = .024), competitive to and more stable than the TNM staging system (C-index = 0.842, p = .003 and C-index = 0.765, p = .050) in the training cohort and the validation cohort.

Conclusions

Through investigating a large one-institutional cohort, the quantitative multi-modalities MRI image phenotypes reveal distinct survival subtypes.

Key Points

• Radiomics phenotype of MRI revealed the subtype of nasopharyngeal carcinoma (NPC) patients with distinct survival patterns.

• The slice-wise analysis method on MRI helps to stratify patients and provides superior prognostic performance over the TNM staging method.

• Risk estimation using the highest risk among slices performed better than using the majority risk in prognosis.

Keywords

Nasopharynx Magnetic resonance imaging Radiomics Survival analysis 

Abbreviations and acronyms

AJCC

American Joint Committee on Cancer

CI

Confidence interval

EBV

Epstein-Barr virus

GC

Gastric cancer

IMRT

Intensity-modulated radiation therapy

LRFS

Locoregional recurrence-free survival

NPC

Nasopharyngeal carcinoma

PGL

Primary gastric lymphoma

ROI

Region of interest

TNM

Tumor, node and metastasis

UICC

Union for International Cancer Control

Notes

Funding

This work was supported by grants from the National Natural Science Foundation of China (no.61771007, no.81572652), Health & Medical Collaborative Innovation Project of Guangzhou City, China (grants 201604020003, 201803010021), Science and Technology Planning Projects of Guangdong Province (2016A010101013, 2017B020226004), and the Fundamental Research Fund for the Central Universities (2017ZD051).

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Hong-min Cai.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was waived by the Institutional Review Board.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• retrospective

• diagnostic or prognostic study

• performed at one institution

Supplementary material

330_2019_6075_MOESM1_ESM.doc (76 kb)
ESM 1 (DOC 76 kb)

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Copyright information

© European Society of Radiology 2019

Authors and Affiliations

  • En-Hong Zhuo
    • 1
  • Wei-Jing Zhang
    • 2
  • Hao-Jiang Li
    • 2
  • Guo-Yi Zhang
    • 3
  • Bing-Zhong Jing
    • 2
  • Jian Zhou
    • 2
  • Chun-Yan Cui
    • 2
  • Ming-Yuan Chen
    • 2
  • Ying Sun
    • 2
  • Li-Zhi Liu
    • 2
    Email author
  • Hong-Min Cai
    • 1
    • 4
    Email author
  1. 1.School of Computer Science and EngineeringSouth China University of TechnologyGuangzhouPeople’s Republic of China
  2. 2.State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouPeople’s Republic of China
  3. 3.Department of Radiation Oncology, Cancer CenterFirst People’s Hospital of FoshanFoshanPeople’s Republic of China
  4. 4.Guangdong Provincial Key Lab of Computational Intelligence and Cyberspace Information, South China University of TechnologyGuangzhouPeople’s Republic of China

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