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ERAMRS: a new MR scoring system for early rheumatoid arthritis of the wrist

  • Fan Xiao
  • James F. GriffithEmail author
  • Andrea L. Hilkens
  • Jason C. S. Leung
  • Jiang Yue
  • Ryan K. L. Lee
  • David K. W. Yeung
  • Lai-Shan Tam
Musculoskeletal

Abstract

Purpose

To (i) devise a new semi-quantitative scoring system known as Early Rheumatoid Arthritis Magnetic Resonance Score (ERAMRS) to assess inflammation of the wrist on magnetic resonance imaging in early rheumatoid arthritis and to (ii) test ERAMRS and other MR scoring systems against everyday used clinical scorings.

Materials and methods

One hundred six treatment-naïve patients (81 females, 25 males, mean age 53 ± 12 years) with early rheumatoid arthritis (ERA) underwent clinical/serological testing as well as 3-T MRI examination of the most symptomatic wrist. Clinical assessment included Disease Activity Score-28 and Health Assessment Questionnaire; erythrocyte sedimentation rate and C-reactive protein were measured. MR imaging data was scored in all patients using three devised MR semi-quantitative scoring systems, namely, the (a) ERAMRS system, (b) Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) system, and the (c) McQueen Score system.

Results

Synovitis was present in 106 (100%), tenosynovitis in 98 (92%), and bone marrow edema in 84 (79%) of 106 ERA wrists. ERAMRS had the highest correlation with clinical disease activity scores (r = 0.476, p < 0.001) and serological parameters (r = 0.562, p < 0.001). RAMRIS system had the lowest correlation (r = 0.369, p < 0.001 for clinical disease activity; r = 0.436, p < 0.001 for serological parameters). RAMRIS synovitis subscore had a lower correlation than ERAMRS for clinical disease activity (r = 0.410, p < 0.001) and for serological parameters (r = 0.456, p < 0.001).

Conclusion

The ERAMRS system, designed to grade inflammation on wrist MRI in ERA, provided the best correlation with all clinical scoring systems and serological parameters, indicating its improved clinical relevance over other MR scoring systems.

Key Points

We devised a clinically relevant, easy-to-use semi-quantitative scoring system for scoring inflammation on MRI of the wrist in patients with early rheumatoid arthritis.

ERAMRS system showed better correlation with all clinical and serological assessment of inflammation in patients with early rheumatoid arthritis indicating its improved clinical relevance over other MR scoring systems.

Keywords

Early rheumatoid arthritis Magnetic resonance imaging Semi-quantitative scoring system Clinical correlation 

Abbreviations

CRP

C-reactive protein

DAS28

Disease Activity Score-28 Calculator

ERA

Early rheumatoid arthritis

ERAMRS

Early Rheumatoid Arthritis Magnetic Resonance Score

ESR

Erythrocyte sedimentation rate

HAQ

Health Assessment Questionnaire

MRI

Magnetic resonance imaging

RAMRIS

Rheumatoid Arthritis Magnetic Resonance Imaging Score

Notes

Funding

The authors state that this work has not received any funding.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is James F. Griffith.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

One of the authors has significant statistical expertise.

Jason Chi Shun Leung

The Chinese University of Hong Kong Jockey Club Centre for Osteoporosis Care and Control

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• prospective

• cross-sectional study

• performed at one institution

Supplementary material

330_2019_6060_MOESM1_ESM.docx (41 kb)
ESM 1 (DOCX 41 kb)

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Copyright information

© European Society of Radiology 2019

Authors and Affiliations

  1. 1.Department of Imaging & Interventional RadiologyPrince of Wales Hospital, The Chinese University of Hong KongShatin, N.T.Hong Kong
  2. 2.Department of Jockey Club Centre for Osteoporosis Care and Control, Prince of Wales HospitalThe Chinese University of Hong KongShatin, N.T.Hong Kong
  3. 3.Department of Medicine & Therapeutics, Prince of Wales HospitalThe Chinese University of Hong KongShatin, N.T.Hong Kong

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