FLAIR vascular hyperintensity in acute stroke is associated with collateralization and functional outcome
Fluid-attenuated inversion recovery vascular hyperintensity (FVH) is frequently found in stroke patients after intracranial arterial occlusion, but the prognostic value of FVH findings is unclear. We assessed whether FVH is associated with cerebral collateral status and functional outcome in patients with acute stroke patients receiving endovascular therapy.
FVH score, American Society of Interventional and Therapeutic Neuroradiology (ASITN) grade, the functional outcome at 3 months (modified Rankin Scale (mRS)), and other clinical data were collected for 37 acute stroke patients with large vessel occlusion (LVO) receiving MRI before and after endovascular therapy. Statistical analysis was performed to predict functional outcome after stroke.
The good functional outcome group (n = 16) had a higher FVH1 (FVH before therapy) score (4.63 ± 1.20 vs 3.14 ± 1.15; p = 0.001) and ASITN grade (3.31 ± 0.48 vs 2.00 ± 1.22; p < 0.001) and a lower FVH2 (FVH after therapy) score than the poor functional outcome group (n = 21; 0.125 ± 0.50 vs 1.44 ± 2.16; p = 0.030). mRS at 3 months was negatively correlated with FVH1 (r = − 0.525, p = 0.001) and the ASITN grade (r = − 0.478, p = 0.003) and positively correlated with FVH2 (r = 0.376, p = 0.034). FVH1 (OR, 0.085; 95% CI, 0.013–0.577; p = 0.012) and FVH2 (OR, 2.724; 95% CI, 1.061–6.996; p = 0.037) were independently associated with functional outcome in multivariable logistic regression analysis.
Assessing FVH before and after therapy in acute stroke patients with LVO might be useful for predicting functional outcome after stroke.
• Fluid-attenuated inversion recovery vascular hyperintensity is a circular or serpentine brightening in the brain parenchyma or cortical surface bordering the subarachnoid space on MR imaging.
• A prospective study showed that fluid-attenuated inversion recovery vascular hyperintensity is associated with cerebral collateral circulation and prognosis.
• Fluid-attenuated inversion recovery vascular hyperintensity helps clinicians to predict the prognosis of patients with acute stroke.
KeywordsStroke Magnetic resonance imaging Angiography Collateral circulation Prognosis
American Society of Interventional and Therapeutic Neuroradiology
Alberta Stroke Program Early CT Score
Computed tomography angiography
Digital subtraction angiography
Fluid-attenuated inversion recovery
Fluid-attenuated inversion recovery vascular hyperintensity
Large vessel occlusion
Magnetic resonance angiography
Magnetic resonance imaging
Modified Rankin Scale
Modified Thrombolysis in Cerebral Ischemia
National Institutes of Health Stroke Scale
LJ and Y-C C designed the experiment, collected the data, performed the analysis, and wrote the paper. HZ, MP, HC, WG, and QX helped collect the data and perform the analysis. XY and YM contributed to the discussion and manuscript revision.
This study has received funding by Jiangsu Provincial Special Program of Medical Science (No. BE2017614).
Compliance with ethical standards
The scientific guarantor of this publication is Xindao Yin.
Conflict of interest
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
Statistics and biometry
No complex statistical methods were necessary for this paper.
All patients in this study have written informed consent before examined.
Institutional Review Board approval was obtained.
• diagnostic or prognostic study
• performed at one institution