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Diagnostic performance of [18F]FDG-PET/MRI for liver metastasis in patients with primary malignancy: a systematic review and meta-analysis

  • Seung Baek Hong
  • Sang Hyun ChoiEmail author
  • Kyung Won Kim
  • Seong Ho Park
  • So Yeon Kim
  • So Jung Lee
  • Seung Soo Lee
  • Jae Ho Byun
  • Moon-Gyu Lee
Magnetic Resonance
  • 31 Downloads

Abstract

Objectives

To systematically determine the diagnostic accuracy of 18-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ([18F]FDG-PET/MRI) for the detection of liver metastases and evaluate the sources of heterogeneity in the reported results.

Methods

PubMed and EMBASE databases were searched up until December 31, 2017, to identify original research studies reporting the diagnostic performance (Se and Sp) of PET/MRI for liver metastases, in comparison with PET/CT. Study quality was assessed using QUADAS-2. The summary Se and Sp of the studies were estimated using hierarchical modeling methods. To determine causes of study heterogeneity, the presence of a threshold effect was analyzed, and meta-regression analysis was performed.

Results

Of 546 articles screened, eight suitable articles were identified, with seven for per-lesion analysis, and four for per-patient analysis. The meta-analytic summary Se and Sp for per-patient-based analysis were 99.2% (95% CI, 31.4–100.0%, I2 = 89.4%) and 98.6% (95% CI, 84.0–99.9%, I2 = 0.0%), respectively, while for per-lesion-based analysis they were 95.4% (95% CI, 78.3–99.2%, I2 = 99.7%) and 99.3% (95% CI, 93.8–99.9%, I2 = 96.5%). PET/MRI showed higher Se (95.4% vs. 68.3%) and Sp (99.3% vs. 95.8%) than PET/CT. Meta-regression analysis showed five significant factors affecting study heterogeneity: study subject characteristics, study design, MRI technique (DWI, HBP after injection of liver-specific contrast media), imaging review method, and reference standard.

Conclusion

The diagnostic accuracy of [18F]FDG-PET/MRI for liver metastasis was high overall, but substantial heterogeneity was found. Further randomized controlled studies or prospective studies are needed to investigate the role of PET/MRI in liver metastasis in comparison with PET/CT.

Key Points

• [ 18 F]FDG-PET/MRI has high meta-analytic Se and Sp for the diagnosis of liver metastasis.

• PET/MRI using DWI and HBP images significantly increased diagnostic accuracy.

• Study heterogeneity was associated with subject characteristics, study design, MRI technique, image review method, and reference standard.

Keywords

Fluorodeoxyglucose F18 Positron emission tomography-computed tomography Magnetic resonance imaging Neoplasms Liver 

Abbreviations

AHRQ

Agency for Healthcare Research and Quality

CI

Confidence intervals

DWI

Diffusion-weighted imaging

FN

False negatives

FP

False positives

HBP

Hepatobiliary phase

HSROC

Hierarchical summary receiver operating characteristic

MRI

Magnetic resonance imaging

PET

Positron emission tomography

PRISMA

Preferred Reporting Items for Systematic Reviews and Meta-Analyses

QUADAS

Quality Assessment of Diagnostic Accuracy Studies

Se

Sensitivity

Sp

Specificity

TN

True negatives

TP

True positives

Notes

Funding

This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number HI18C2383).

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Sang Hyun Choi.

Conflict of interest

The authors declare that they have no conflict of interest.

Statistics and biometry

One of the authors (Sang Hyun Choi) has significant statistical expertise.

Informed consent

Written informed consent was not required for this study because this study was a meta-analysis.

Ethical approval

Institutional review board approval was not required because this study was a meta-analysis.

Methodology

• Meta-analysis

• Diagnostic study

• Performed at one institution

Supplementary material

330_2018_5909_MOESM1_ESM.docx (295 kb)
ESM 1 (DOCX 294 kb)

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Copyright information

© European Society of Radiology 2019

Authors and Affiliations

  1. 1.Department of Radiology and the Research Institute of RadiologyUniversity of Ulsan College of Medicine, Asan Medical CenterSeoulSouth Korea
  2. 2.Department of RadiologyPusan National University of HospitalBusanSouth Korea

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