Better understanding of acute gouty attack using CT perfusion in a rabbit model

  • Yabin Hu
  • Qing YangEmail author
  • Yanyan Gao
  • Xuexin Guo
  • Yongjian Liu
  • Can Li
  • Yanmeng Du
  • Lei Gao
  • Dezheng Sun
  • Congcong Zhu
  • Mi Yan



To assess hemodynamic changes related to acute gouty knee arthritis in a rabbit with CT perfusion (CTP)


Forty-two rabbits were randomly separated into two groups: the treated group of 30 and the control group of 12. The right knee was injected with monosodium urate solution and polymyxin in the treated group and saline and polymyxin in the control group. At 2, 16, 32, 48, 60, and 72 h after injection, five rabbits from the treated group and two rabbits from the control group were selected for CTP. At each time point, blood flow (BF), blood volume (BV), and clearance rate (CL) were measured, and microvessel density (MVD) was evaluated with a microscope.


In the treated group, BF, BV, CL, and MVD were significantly higher than in the control group (p < 0.001). Differences within paired comparison of BV, BF, CL, and MVD were all significant (all p < 0.001). Peak time of BV, BF, and MVD was 32 h and 48 h for CL. After multivariate stepwise linear regression analysis, BV was linearly associated with MVD and vice versa, which also applied to BF with MVD and BF with CL, separately. The ascending rate of MVD was the highest among that of all parameters; so was the descending rate of CL.


CTP in this rabbit knee model accurately detected hemodynamic changes during a gouty attack.

Key Points

• Acute gouty arthritis can be evaluated with CTP in a rabbit knee model.

• Following injection of MSU crystals, producing an acute gouty attack, CTP successfully assessed hemodynamic changes.

• The ascending rate of MVD was the highest among that of all parameters; so was the descending rate of CL.


Perfusion imaging Multidetector computed tomography Arthritis, gouty Rabbits 



Three dimensional


Blood flow


Blood volume


Clearance rate


Computed tomography perfusion


Intraclass correlation coefficient


Monosodium urate


Microvessel density



This study has received funding from The science and technology development of Shandong province (2011GSF11834).

Compliance with ethical standards


The scientific guarantor of this publication is Qing Yang.

Conflict of interest

The authors declare that they have no competing interests.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Approval from the institutional animal care committee was obtained.

Ethical approval

Institutional Review Board approval was obtained.


• Prospective

• Randomized controlled trial/experimental

• Performed at one institution


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Copyright information

© European Society of Radiology 2018

Authors and Affiliations

  1. 1.Department of RadiologyAffiliated Hospital (Laoshan Hospital) of Qingdao UniversityQingdaoChina
  2. 2.Department of Radiology, Zhongshan Hospital, Fudan UniversityShanghai Institute of Medical ImagingShanghaiChina
  3. 3.Department of EndocrinologyAffiliated Hospital (Laoshan Hospital) of Qingdao UniversityQingdaoChina
  4. 4.Department of RadiologyDongying People’s HospitalDongyingChina
  5. 5.Department of RadiologyHiser Medical Center of QingdaoQingdaoChina
  6. 6.Department of CTJuancheng People’s HospitalHezeChina
  7. 7.CT scan RoomJinan Fourth HospitalJinanChina
  8. 8.Department of CTThe Third Hospital of Hebei Medical UniversityShijiazhuangChina
  9. 9.Department of RadiologyQingdao Municipal HospitalQingdaoChina

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