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European Radiology

, Volume 29, Issue 3, pp 1094–1103 | Cite as

Characteristics and associated risk factors of diverticular disease assessed by magnetic resonance imaging in subjects from a Western general population

  • Corinna Storz
  • Theresa Rothenbacher
  • Susanne Rospleszcz
  • Jakob Linseisen
  • Helmut Messmann
  • Carlo N. De Cecco
  • Jürgen Machann
  • Roberto Lorbeer
  • Lena S. Kiefer
  • Elke Wintermeyer
  • Sophia D. Rado
  • Konstantin Nikolaou
  • Stefanie Elser
  • Wolfgang Rathmann
  • Maximilian F. Reiser
  • Annette Peters
  • Christopher L. Schlett
  • Fabian BambergEmail author
Gastrointestinal
  • 116 Downloads

Abstract

Objectives

Diverticular disease represents an increasing pathology and healthcare burden worldwide. Our aim was to study the prevalence, extent and distribution of asymptomatic diverticular disease assessed by magnetic resonance imaging (MRI) in a sample of a Western population.

Methods

Subjects from a population-based cohort study who underwent 3-T MRI were analyzed for the prevalence and extent of diverticula of the colon using an isotropic VIBE-Dixon gradient-echo sequence. The extent of diverticular disease was categorized according to the number of diverticula in each colonic segment. Univariate and adjusted analyses were performed to assess associated characteristics and risk factors.

Results

Among 393 subjects included in the analysis (56.4 ± 9.2 years, 57.5% males), 164 (42%) had diverticular disease, with the highest prevalence in the left-sided colonic segments (93% diverticular disease in the descending and sigmoid segment). Subjects with advanced diverticular disease were older (62.1 vs. 54.4 years) and had a higher body mass index (BMI), LDL cholesterol levels and systolic blood pressure (30.2 ± 5.1 vs. 27.8 ± 4.9 kg/m2, 149.8 ± 29.3 vs. 135.2 ± 32.9 mg/dl and 128.2 ± 14.1 vs. 118.4 ± 16.1 mmHg, respectively; all p > 0.003) compared with subjects without diverticular disease. In contrast, no significant correlation could be found for gender, physical activity, smoking status and alcohol consumption (all p > 0.31). Intra-rater reliability was excellent for all colonic segments (intra-class correlation [ICC] = 0.99-1.00), and inter-rater reliability was excellent for left- and right-sided colonic segments (ICC = 0.84-0.97).

Conclusions

These findings provide insights into the disease mechanism of asymptomatic diverticular disease and may help to improve prevention of diverticulosis and its associated complications.

Key Points

• Overall prevalence of asymptomatic diverticular disease assessed by MRI was 42%, affecting predominantly the left-sided colon.

• Asymptomatic diverticular disease was associated with age and cardiometabolic risk factors.

• Magnetic resonance imaging reveals insights into the pathophysiologic mechanism of asymptomatic diverticular disease.

Keywords

Diverticular disease Magnetic resonance imaging Colon Epidemiology 

Abbreviations

BMI

Body mass index

CT

Computed tomography

CTC

Computed tomography colonography

ICC

Intraclass correlation coefficient

LDL

Low-density-lipoprotein

MRI

Magnetic resonance imaging

OGTT

Oral glucose tolerance test

OR

Odds ratio

Notes

Funding

This study was funded by the German Research Foundation (DFG, Bonn, Germany), the German Centre for Cardiovascular Disease Research (DZHK, Berlin, Germany) and the German Centre for Diabetes Research (DZD e.V., Neuherberg, Germany).

The KORA study was initiated and financed by the Helmholtz Zentrum München-German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Fabian Bamberg, MD, MPH.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

Two of the authors (SR, RL) have significant statistical expertise.

Informed consent

Written informed consent was obtained from all subjects in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• prospective

• population based

• case-control study

• performed at one institution

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Copyright information

© European Society of Radiology 2018

Authors and Affiliations

  • Corinna Storz
    • 1
  • Theresa Rothenbacher
    • 1
  • Susanne Rospleszcz
    • 2
  • Jakob Linseisen
    • 2
    • 3
  • Helmut Messmann
    • 4
  • Carlo N. De Cecco
    • 5
  • Jürgen Machann
    • 6
    • 7
    • 8
  • Roberto Lorbeer
    • 9
  • Lena S. Kiefer
    • 1
  • Elke Wintermeyer
    • 10
  • Sophia D. Rado
    • 1
  • Konstantin Nikolaou
    • 1
  • Stefanie Elser
    • 1
  • Wolfgang Rathmann
    • 11
  • Maximilian F. Reiser
    • 9
  • Annette Peters
    • 2
    • 12
    • 13
    • 14
  • Christopher L. Schlett
    • 15
  • Fabian Bamberg
    • 1
    Email author
  1. 1.Department of Diagnostic and Interventional RadiologyUniversity Hospital TuebingenTuebingenGermany
  2. 2.Institute of EpidemiologyHelmholtz Centre Munich, German Research Center for Environmental HealthNeuherbergGermany
  3. 3.University Center of Health Sciences at Klinikum Augsburg (UNIKA-T)Ludwig Maximilian University of MunichAugsburgGermany
  4. 4.Department of Internal Medicine IIIKlinikum AugsburgAugsburgGermany
  5. 5.Department of RadiologyMedical University of South CarolinaCharlestonUSA
  6. 6.Section on Experimental Radiology, Department of Diagnostic and Interventional RadiologyUniversity Hospital TuebingenTuebingenGermany
  7. 7.Institute for Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of TuebingenTuebingenGermany
  8. 8.German Center for Diabetes Research (DZD)TuebingenGermany
  9. 9.Department of RadiologyLudwig Maximilian University HospitalMunichGermany
  10. 10.Siegfried Weller Institute for Trauma ResearchBG Trauma Center Tübingen, Eberhard Karls University TübingenTübingenGermany
  11. 11.Department of Biometry and EpidemiologyGerman Diabetes CenterDüsseldorfGermany
  12. 12.German Center for Cardiovascular Disease Research (DZHK e.V.)MunichGermany
  13. 13.Institute for Cardiovascular PreventionLudwig Maximilian University-HospitalMunichGermany
  14. 14.Chair of EpidemiologyLudwig Maximilian UniversityMunichGermany
  15. 15.Department of Radiology, Diagnostic and Interventional RadiologyUniversity of HeidelbergHeidelbergGermany

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