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European Radiology

, Volume 29, Issue 3, pp 1469–1478 | Cite as

Role of second high-intensity focused ultrasound (HIFU) treatment for unsatisfactory benign thyroid nodules after first treatment

  • Brian Hung-Hin LangEmail author
  • Yu-Cho Woo
  • Keith Wan-Hang Chiu
Ultrasound

Abstract

Background

We aimed to assess the efficacy and safety of second high-intensity focused ultrasound (HIFU) ablation treatment in benign thyroid nodules that had failed to shrink by > 50% 6 months after the first treatment.

Methods

Twenty-eight patients who did not achieve 50% volume reduction at 6 months after the first HIFU treatment underwent a second HIFU treatment. Nodule volume was measured on ultrasound at baseline, 3 months and 6 months. Extent of nodule shrinkage (by volume reduction ratio) (VRR) = [Baseline volume – volume at 6 months]/[Baseline volume] * 100. Treatment success was defined as VRR > 50%. Obstructive symptom score (by 0–10 visual analogue scale, VAS) was evaluated for 6 months after treatment.

Results

No complications occurred after the second treatment. The mean 6-month VRR was 21.78 ± 16.87% with a median (range) of 16.16 (1.63–54.07)%. At 6 months, only two (7.1%) patients achieved treatment success, while nine (32.1%) patients had VRR < 10%. However, relative to baseline (3.96 ± 1.04), the mean VAS significantly improved at 3 and 6 months (2.96 ± 1.43, p<0.001 and 2.58 ± 1.39, p<0.001, respectively). There was a significant correlation between VRR and improvement in VAS score at 6 months (ρ=0.438, p=0.025). Greater nodule volume before the second treatment (OR=1.169, 95% CI=1.004–1.361, p=0.045) was a significant factor for greater VRR after the second treatment.

Conclusions

Although subjective obstructive symptoms continued to improve after the second treatment, the actual extent of nodule shrinkage was small. Larger-volume nodules tended to shrink more significantly than smaller-volume nodules in the second treatment.

Key Points

Second treatment resulted in small shrinkage in unsatisfactory nodules after first treatment.

• Obstructive symptoms tended to continue to improve after second treatment.

• Larger-size nodules tended to respond better in the second treatment.

Keywords

Interventional ultrasonography High-intensity focused ultrasound ablation Treatment efficacy Ultrasound imaging Ablation techniques 

Abbreviations

HIFU

High-intensity focused ultrasound

TSH

Thyroid stimulating hormone

US

Ultrasonography

VCP

Vocal cord palsy

VRR

Volume reduction ratio

Notes

Acknowledgements

We would like to thank Mr. Hill Yu and Ms. Li Wing Kar for conducting all the symptom (or VAS score) assessments for the entire study period and Professor Stephen Cheng (Head of Department of Surgery, University of Hong Kong) for agreeing to be the guarantor of this paper.

Funding

The authors state that this work has not received any funding.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Professor Stephen Cheng (Head of Department).

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• Retrospective

• Observational

• Single institution

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Copyright information

© European Society of Radiology 2018

Authors and Affiliations

  1. 1.Department of SurgeryThe University of Hong KongHong KongChina
  2. 2.Department of SurgeryQueen Mary HospitalHong KongChina
  3. 3.Department of MedicineThe University of Hong KongHong KongChina
  4. 4.Department of RadiologyThe University of Hong KongHong KongChina

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