Changes in sensorimotor-related thalamic diffusion properties and cerebrospinal fluid hydrodynamics predict gait responses to tap test in idiopathic normal-pressure hydrocephalus
To compare diffusion tensor (DT)-derived indices from the thalamic nuclei and cerebrospinal fluid (CSF) hydrodynamic parameters for the prediction of gait responsiveness to the CSF tap test in early iNPH patients.
In this study, 22 patients with iNPH and 16 normal controls were enrolled with the approval of an institutional review board. DT imaging and phase-contrast magnetic resonance imaging were performed in patients and controls to determine DT-related indices of the sensorimotor-related thalamic nuclei and CSF hydrodynamics. Gait performance was assessed in patients using gait scale before and after the tap test. The Mann-Whitney U test and receiver operating characteristic (ROC) curve analysis were applied to compare group differences between patients and controls and assess the predictive performance of gait responsiveness to the tap test in the patients.
Fractional anisotropy (FA) and axial diffusivity showed significant increases in the ventrolateral (VL) and ventroposterolateral (VPL) nuclei of the iNPH group compared with those of the control group (p < 0.05). The predictions of gait responsiveness of ventral thalamic FA alone (area under the ROC curve [AUC] < 0.8) significantly outperformed those of CSF hydrodynamics alone (AUC < 0.6). The AUC curve was elevated to 0.812 when the CSF peak systolic velocity and FA value were combined for the VPL nucleus, yielding the highest sensitivity (0.769) and specificity (0.778) to predict gait responses.
Combined measurements of sensorimotor-related thalamic FA and CSF hydrodynamics can provide potential biomarkers for gait response to the CSF tap test in patients with iNPH.
• Ventrolateral and ventroposterolateral thalamic FA may predict gait responsiveness to tap test.
• Thalamic neuroplasticity can be assessed through DTI in idiopathic normal-pressure hydrocephalus.
• Changes in the CST associated with gait control could trigger thalamic neuroplasticity.
• Activities of sensorimotor-related circuits could alter in patients with gait disturbance.
• Management of patients with iNPH could be more appropriate.
KeywordsHydrocephalus, normal pressure Diffusion tensor imaging Gait Neuronal plasticity Thalamus
Diffusion tensor imaging
Idiopathic normal pressure hydrocephalus
We acknowledge Wallace Academic Editing for editing this manuscript.
This study has received funding by grants from the Ministry of Science and Technology, Taipei, Taiwan, grant NSC 97-2314-B-016-028-MY3 and grant MOST 106-2221-E-038-002.
Compliance with ethical standards
The scientific guarantor of this publication is Dr. Cheng-Yu Chen.
Conflict of interest
The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
Statistics and biometry
No complex statistical methods were necessary for this paper.
Written informed consent was obtained from all subjects (patients) in this study.
Institutional Review Board approval was obtained.
• performed at one institution
- 26.Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate a practical and powerful approach to multiple testing. J R Stat Soc Series B 57:289–300Google Scholar
- 33.Bornschlegl M, Asanuma H (1987) Importance of the projection from the sensory to the motor cortex for recovery of motor function following partial thalamic lesion in the monkey. Brain Res 437:121–130. https://doi.org/10.1016/0006-8993(1087)91533-91532 CrossRefPubMedGoogle Scholar