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European Radiology

, Volume 28, Issue 11, pp 4900–4908 | Cite as

Diagnostic accuracy of 3T magnetic resonance imaging in the preoperative localisation of parathyroid adenomas: comparison with ultrasound and 99mTc-sestamibi scans

  • Renato Argirò
  • Daniele Diacinti
  • Beatrice Sacconi
  • Angelo Iannarelli
  • Davide Diacinti
  • Cristiana Cipriani
  • Daniela Pisani
  • Elisabetta Romagnoli
  • Marco Biffoni
  • Cira Di Gioia
  • Jessica Pepe
  • Mario Bezzi
  • Claudio Letizia
  • Salvatore Minisola
  • Carlo Catalano
Head and Neck

Abstract

Objectives

To evaluate the diagnostic performance of 3TMRI in comparison with ultrasound (US) and 99mTc-sestamibi scan for presurgical localisation of parathyroid adenomas (PTAs) in patients with primary hyperparathyroidism (PHPT).

Methods

Fifty-seven patients affected by PHPT were prospectively enrolled and underwent US, 99mTc-sestamibi and 3TMRI. T2-weighted and post-contrast T1-weighted Iterative decomposition of water and fat with Echo Asymmetry and Least squares estimation (IDEAL) sequences were acquired. Diagnostic performance of US, 99mTc-sestamibi and MRI in localising PTAs to correct quadrant were compared according to surgical and pathological findings.

Results

According to surgical findings, US correctly localised 41/46 PTAs (sensitivity of 89.1%; specificity 97.5%; PPV 93.1% and NPV 95.6%); 99mTc-sestamibi correctly localised 38/46 PTAs (sensitivity 83.6%, specificity 98.3%, PPV 95% and NPV 93.7%). US and 99mTc-sestamibi combined had a sensitivity of 93.4% (43/46 PTAs), specificity of 98.3%, PPV 95% and NPV 98.3%. MRI correctly localised 45/46 PTAs (sensitivity 97.8%; specificity 97.5%; PPV 93.7% and NPV 99.2%). MRI was able to detect six adenomas missed by 99mTc-sestamibi and two adenomas missed by US. MRI and US were able to detect all enlarged parathyroid glands in patients with multiglandular disease. MRI identified six of seven ectopic adenomas.

Conclusions

Our study demonstrated high diagnostic performance of 3T MRI in the preoperative PTAs quadrant localisation, as well as in patients with multiglandular disease and ectopic PTAs. MRI may be preferred to adequately select patient candidates for minimally invasive parathyroidectomy (MIP).

Key Points

PTA(s) quadrant localisation by 3TMRI was more accurate than US+99mTc-sestamibi.

MRI identified all enlarged glands in multiglandular disease similarly to US.

MRI identified 6/7 ectopic PTAs similarly to 99mTc-sestamibi.

Presurgical PTA(s) localisation by 3TMRI select the optimal candidates for MIP.

Keywords

Parathyroid adenoma Surgery Magnetic resonance imaging Ultrasonography Scintigraphy 

Abbreviations

CI

Confidence interval

CT

Computed tomography

MIP

Minimally invasive parathyroidectomy

MRI

Magnetic resonance imaging

PHPT

Primary hyperparathyroidism

PPV

Positive predictive value

PTA(s)

Parathyroid adenoma(s)

PTH

Parathyroid hormone

US

Ultrasound

Notes

Funding

The authors state that this work has not received any funding.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Prof. Carlo Catalano

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Ethical approval

Institutional Review Board approval was obtained

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Methodology

• prospective

• observational study

• performed at one institution

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Copyright information

© European Society of Radiology 2018

Authors and Affiliations

  • Renato Argirò
    • 1
    • 2
  • Daniele Diacinti
    • 2
  • Beatrice Sacconi
    • 2
    • 3
  • Angelo Iannarelli
    • 2
  • Davide Diacinti
    • 2
  • Cristiana Cipriani
    • 4
  • Daniela Pisani
    • 5
  • Elisabetta Romagnoli
    • 6
  • Marco Biffoni
    • 7
  • Cira Di Gioia
    • 2
  • Jessica Pepe
    • 4
  • Mario Bezzi
    • 2
  • Claudio Letizia
    • 4
  • Salvatore Minisola
    • 4
  • Carlo Catalano
    • 2
  1. 1.Department of Radiology, Interventional Radiology UnitOspedale M.G. Vannini – Figlie di San CamilloRomaItaly
  2. 2.Department of Radiological Sciences, Oncology and PathologySapienza UniversityRomeItaly
  3. 3.Center for Life Nano Science SapienzaIstituto Italiano di TecnologiaRomeItaly
  4. 4.Department of Clinical SciencesSapienza UniversityRomeItaly
  5. 5.Department of Clinical and Molecular MedicineSapienza UniversityRomeItaly
  6. 6.Department of Experimental MedicineSapienza UniversityRomeItaly
  7. 7.Department of Surgery SciencesSapienza UniversityRomeItaly

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