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European Radiology

, Volume 28, Issue 9, pp 3591–3600 | Cite as

Gd-EOB-DTPA-enhanced T1 relaxometry for assessment of liver function determined by real-time 13C-methacetin breath test

  • Michael Haimerl
  • Irene Fuhrmann
  • Stefanie Poelsterl
  • Claudia Fellner
  • Marcel D. Nickel
  • Kilian Weigand
  • Marc H. Dahlke
  • Niklas Verloh
  • Christian Stroszczynski
  • Philipp Wiggermann
Gastrointestinal

Abstract

Objectives

To determine whether liver function as determined by intravenous administration of 13C-methacetin and continuous real-time breath analysis can be estimated quantitatively from gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) relaxometry.

Methods

Sixty-six patients underwent a 13C-methacetin breath test (13C-MBT) for evaluation of liver function and Gd-EOB-DTPA-enhanced T1-relaxometry at 3 T. A transverse 3D VIBE sequence with an inline T1 calculation based on variable flip angles was acquired prior to (T1 pre) and 20 min post-Gd-EOB-DTPA (T1 post) administration. The reduction rate of T1 relaxation time (rrT1) and T1 relaxation velocity index (∆R1) between pre- and post-contrast images was evaluated. 13C-MBT values were correlated with T1post, ∆R1 and rrT1, providing an MRI-based estimated 13C-MBT value. The interobserver reliability was assessed by determining the intraclass correlation coefficient (ICC).

Results

Stratified by three different categories of 13C-MBT readouts, there was a constant increase of T1 post with increasing progression of diminished liver function (p ≤ 0.030) and a constant significant decrease of ∆R1 (p ≤ 0.025) and rrT1 (p < 0.018) with progression of liver damage as assessed by 13C-methacetin breath analysis. ICC for all T1 relaxation values and indices was excellent (> 0.88). A simple regression model showed a log-linear correlation of 13C-MBT values with T1post (r = 0.57; p < 0.001), ∆R1 (r = 0.59; p < 0.001) and rrT1 (r = 0.70; p < 0.001).

Conclusion

Liver function as determined using real-time 13C-methacetin breath analysis can be estimated quantitatively from Gd-EOB-DTPA-enhanced MR relaxometry.

Key Points

Gd-EOB-DTPA-enhanced T1 relaxometry quantifies liver function

Gd-EOB-DTPA-enhanced MR relaxometry may provide parameters for assessing liver function before surgery

Gd-EOB-DTPA-enhanced MR relaxometry may be useful for monitoring liver disease progression

Gd-EOB-DTPA-enhanced MR relaxometry has the potential to become a novel liver function index

Keywords

Contrast media Liver diseases Liver function tests Breath test Magnetic resonance imaging 

Abbreviations

13C-MBT

13C-methacetin breath test

Gd-EOB-DTPA

Gadoxetic acid

HCC

Hepatocellular carcinoma

CYP1A2

Hepatocyte-specific cytochrome P450 1A2

ICG

Indocyanine green

LiMAx

Liver maximum capacity

NASH

Non-alcoholic steatohepatitis

OATP

Organic anion transporting peptide

rrT1

Reduction rate of T1 relaxation times

ROI

Region of interest

SI

Signal intensities

∆R1

T1 relaxation velocity index

T1 post

T1-relaxometry measurements 20 min after Gd-EOB-DTPA administration

Notes

Funding

The authors state that this work has not received any funding.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is PD Dr. Philipp Wiggermann.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

One of the authors has significant statistical expertise.

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• retrospective

• case-control study

• performed at one institution

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Copyright information

© European Society of Radiology 2018

Authors and Affiliations

  • Michael Haimerl
    • 1
  • Irene Fuhrmann
    • 1
  • Stefanie Poelsterl
    • 1
  • Claudia Fellner
    • 1
  • Marcel D. Nickel
    • 2
  • Kilian Weigand
    • 3
  • Marc H. Dahlke
    • 4
  • Niklas Verloh
    • 1
  • Christian Stroszczynski
    • 1
  • Philipp Wiggermann
    • 1
  1. 1.Department of RadiologyUniversity Hospital RegensburgRegensburgGermany
  2. 2.MR Applications PredevelopmentSiemens Healthcare GmbHErlangenGermany
  3. 3.Department of Internal Medicine IUniversity Hospital RegensburgRegensburgGermany
  4. 4.Department of SurgeryUniversity Hospital RegensburgRegensburgGermany

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