Computed tomography findings in ABO-incompatible living donor liver transplantation recipients with biliary strictures
- 258 Downloads
To evaluate CT findings of biliary strictures in ABO-incompatible living donor liver transplantation (LDLT) recipients, with emphasis on associated 1-month post-transplantation CT findings, and evaluate clinical outcomes.
Of 351 ABO-incompatible recipients, we retrospectively evaluated CT scans in 65 recipients with biliary stricture. The biliary strictures on CT scans were classified as type A (perihilar) and type B (diffuse). Precedent CT abnormality patterns and the presence of a periportal halo sign at 1-month post-transplantation were evaluated. For each patient, clinical outcomes were evaluated.
Of 65 ABO-incompatible recipients with biliary strictures, 36.9% had type B strictures. Compared with biliary strictures at diagnosis, similar CT abnormality patterns were observed for 84.4% in type A and 86.4% in type B strictures at 1-month post-transplantation. Complex periportal halo signs on the 1-month post-transplantation CT were more frequently noted for type B than type A strictures (86.4% vs. 3.1%, P < 0.001). Progressive clinical outcomes were more frequently observed for type B than type A strictures (79.2% vs. 26.8%, P < 0.001), with a significantly shorter graft survival time (46.4 months vs. 90.8 months, P < 0.001).
CT abnormality patterns and complex periportal halo signs on 1-month post-transplantation CT may be clinically useful for managing biliary strictures in ABO-incompatible LDLT recipients.
• Of ABO-incompatible LDLT recipients, type B biliary stricture incidence was 6.8%.
• Of type B strictures, 86.4% exhibited similar CT abnormality patterns at 1-month post-transplantation.
• Complex periportal halo at 1 month was significantly associated with type B strictures.
• Progressive clinical outcomes were more frequently observed in type B strictures.
KeywordsLiver transplantation Bile ducts Computed tomography Blood group incompatibility Outcome
living donor liver transplantation
model for end-stage liver disease
red blood cell
bile duct opening
bile duct anastomosis
duct to duct
The authors state that this work has not received any funding.
Compliance with ethical standards
The scientific guarantor of this publication is Kyoung Won Kim.
Conflict of interest
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
Statistics and biometry
One of the authors has significant statistical expertise.
Written informed consent was waived by the Institutional Review Board.
Institutional Review Board approval was obtained.
• performed at one institution
- 8.Gore RM, Levine MS (2014) Textbook of gastrointestinal radiology. Elsevier Health SciencesGoogle Scholar