Larger volume and different functional connectivity of the amygdala in women with premenstrual syndrome

  • Demao Deng
  • Yong Pang
  • Gaoxiong Duan
  • Huimei Liu
  • Hai Liao
  • Peng Liu
  • Yanfei Liu
  • Shasha Li
  • Wenfu Chen
  • Danhong Wen
  • Chunmei Xuan
  • Min Li
Magnetic Resonance

Abstract

Objectives

To assess structural and functional changes of the amygdala due to premenstrual syndrome (PMS) using magnetic resonance imaging (MRI).

Methods

Twenty PMS patients and 21 healthy control (HC) subjects underwent a 6-min resting-state fMRI scan during the luteal phase as well as scanning high-resolution T1-weighted images. Subcortical amygdala-related volume and functional connectivity (FC) were estimated between the two groups. Each subject completed a daily record of severity of problems (DRSP) to measure the severity of clinical symptoms.

Results

Greater bilateral amygdalae volumes were found in PMS patients compared with HC subjects, and PMS patients had increased FC between the amygdala and certain regions of the frontal cortex (e.g. medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), right precentral gyrus), the right temporal pole and the insula, as well as decreased FC between the bilateral amygdalae and the right orbitofrontal cortex and right hippocampus. The strength of FC between the right amygdala and right precentral gyrus, left ACC and left mPFC were significantly and positively correlated with DRSP scores in PMS patients.

Conclusions

Our findings may improve our understanding of the neural mechanisms involved in PMS.

Key Points

Functional and structural MRI used to explore amygdala in PMS patients.

Aberrant amygdala structural and functional connectivity were found in PMS patients.

Amygdala strength FC was positively correlated with individual clinical symptom scores.

Keywords

Premenstrual syndrome Amygdala Magnetic resonance imaging Brain Neuroimaging 

Abbreviations

ACC

Anterior cingulate cortex

AN

Affective network

BMI

Body mass index

BOLD

Blood oxygenation level dependent

DMN

Default mode network

DRSP

Daily record of severity of problems

DSM-5

Diagnostic and Statistical Manual of Mental Disorders-5th Edition

EPI

Echo planar imaging

fMRI

Functional magnetic resonance imaging

FOV

Field of view

HC

Healthy control

HIPP

Hippocampus

mPFC

Medial prefrontal cortex

OFC

Orbitofrontal cortex

PMDD

Premenstrual dysphoric disorder

PMS

Premenstrual syndrome

ROI

Region of interest

rs-fMRI

Resting-state functional magnetic resonance imaging

TE

Echo time

TR

Repetition time

Notes

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Demao Deng.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Informed consent

All participants were informed about the experimental procedure and provided written informed consent.

Ethical approval

The study was approved by the Medicine Ethics Committee of First Affiliated Hospital, Guangxi University of Chinese Medicine, Guangxi, China.

Methodology

• prospective

• case-control study

• performed at one institution

Supplementary material

330_2017_5206_MOESM1_ESM.doc (74 kb)
ESM 1 (DOC 74 kb)

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Copyright information

© European Society of Radiology 2017

Authors and Affiliations

  1. 1.Department of Radiology, First Affiliated HospitalGuangxi University of Chinese MedicineNanningChina
  2. 2.Department of Acupuncture, First Affiliated HospitalGuangxi University of Chinese MedicineNanningChina
  3. 3.Life Science Research Center, School of Life Science and TechnologyXidian UniversityXi’anChina
  4. 4.Department of Teaching, First Affiliated HospitalGuangxi University of Chinese MedicineNanningChina

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