MRI features can predict EGFR expression in lower grade gliomas: A voxel-based radiomic analysis
- 827 Downloads
To identify the magnetic resonance imaging (MRI) features associated with epidermal growth factor (EGFR) expression level in lower grade gliomas using radiomic analysis.
270 lower grade glioma patients with known EGFR expression status were randomly assigned into training (n=200) and validation (n=70) sets, and were subjected to feature extraction. Using a logistic regression model, a signature of MRI features was identified to be predictive of the EGFR expression level in lower grade gliomas in the training set, and the accuracy of prediction was assessed in the validation set.
A signature of 41 MRI features achieved accuracies of 82.5% (area under the curve [AUC] = 0.90) in the training set and 90.0% (AUC = 0.95) in the validation set. This radiomic signature consisted of 25 first-order statistics or related wavelet features (including range, standard deviation, uniformity, variance), one shape and size-based feature (spherical disproportion), and 15 textural features or related wavelet features (including sum variance, sum entropy, run percentage).
A radiomic signature allowing for the prediction of the EGFR expression level in patients with lower grade glioma was identified, suggesting that using tumour-derived radiological features for predicting genomic information is feasible.
• EGFR expression status is an important biomarker for gliomas.
• EGFR in lower grade gliomas could be predicted using radiogenomic analysis.
• A logistic regression model is an efficient approach for analysing radiomic features.
KeywordsRadiomics Lower grade glioma EGFR MRI Prediction
Area under the curve
Epidermal growth factor receptor
Magnetic resonance imaging
Receiver operating characteristic
Compliance with ethical standards
The scientific guarantor of this publication is Tao Jiang.
Conflict of interest
The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.
This study has received funding by the National Natural Science Foundation of China (No. 81601452).
Statistics and biometry
Mr Kaibin Xu kindly provided statistical advice for this manuscript.
Written informed consent was not required for this study because the data were collected retrospectively in the study.
Institutional review board approval was obtained.
• diagnostic or prognostic study
• performed at one institution
- 2.Fan X, Wang Y, Zhang C et al (2016) ADAM9 Expression Is associate with glioma tumor grade and histological type, and acts as a prognostic factor in lower-grade gliomas. Int J Mol Sci 17Google Scholar
- 4.Ramos-Suzarte M, Lorenzo-Luaces P, Lazo NG et al (2012) Treatment of malignant, non-resectable, epithelial origin esophageal tumours with the humanized anti-epidermal growth factor antibody nimotuzumab combined with radiation therapy and chemotherapy. Cancer Biol Ther 13:600–605CrossRefPubMedGoogle Scholar
- 11.Yoo RE, Choi SH, Cho HR et al (2013) Tumor blood flow from arterial spin labeling perfusion MRI: a key parameter in distinguishing high-grade gliomas from primary cerebral lymphomas, and in predicting genetic biomarkers in high-grade gliomas. J Magn Reson Imaging 38:852–860CrossRefPubMedGoogle Scholar