Left ventricular regional myocardial motion and twist function in repaired tetralogy of Fallot evaluated by magnetic resonance tissue phase mapping
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We aimed to characterise regional myocardial motion and twist function in the left ventricles (LV) in patients with repaired tetralogy of Fallot (rTOF) and preserved LV global function.
We recruited 47 rTOF patients and 38 age-matched normal volunteers. Tissue phase mapping (TPM) was performed for evaluating the LV myocardial velocity in longitudinal, radial, and circumferential (Vz, Vr, and VØ) directions in basal, middle, and apical slices. The VØ peak-to-peak (PTP) during systolic phases, the rotation angle of each slice, and VØ inconsistency were computed for evaluating LV twist function and VØ dyssynchrony.
As compared to the controls, the rTOF patients presented decreased RV ejection fraction (RVEF) (p = 0.002) and preserved global LV ejection fraction (LVEF). They also demonstrated decreased systolic and diastolic Vz in several LV segments and higher diastolic Vr in the septum (all p < 0.05). A lower VØ PTP, higher VØ inconsistency, and reduced peak net rotation angle (all p < 0.05) were observed. The aforementioned indices demonstrated an altered LV twist function in rTOF patients in an early disease stage.
MR TPM could provide information about early abnormalities of LV regional motion and twist function in rTOF patients with preserved LV global function.
• Patients with rTOF presented significantly reduced systolic and diastolic Vz in the LV.
• rTOF patients demonstrated significantly increased diastolic Vr in the septum.
• Abnormal characteristics of the segmental dynamic velocity evolution were shown in rTOF.
• rTOF patients presented altered circumferential rotation and velocity inconsistency in early stage.
KeywordsTetralogy of Fallot Tissue phase mapping Myocardial motion Twist Ventricular function
peak to peak
repaired tetralogy of Fallot
tissue phase mapping
Parts of the work have been presented in the 23rd Annual Meeting of International Society of Magnetic Resonance in Medicine, Toronto, Canada.
Compliance with ethical standards
The scientific guarantor of this publication is Dr. Hsu-Hsia Peng.
Conflict of interest
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
This study has received funding by the Veterans General Hospitals and University System of Taiwan Joint Research Program (VGHUST103-G3-1-1, VGHUST103-G3-1-2, VGHUST104-G7-7-1, VGHUST104-G7-7-2, and VGHUST104-G7-7-3). This study was also supported in part by Ministry of Science and Technology in Taiwan (NSC 102-2320-B-007-003-MY3).
Statistics and biometry
No complex statistical methods were necessary for this paper.
Written informed consent was obtained from all subjects (patients) in this study.
Institutional Review Board approval was obtained.
• cross sectional study
• performed at one institution
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