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European Radiology

, Volume 27, Issue 9, pp 3867–3876 | Cite as

Poorly-differentiated colorectal neuroendocrine tumour: CT differentiation from well-differentiated neuroendocrine tumour and poorly-differentiated adenocarcinomas

  • Ji Hee Kang
  • Se Hyung KimEmail author
  • Joon Koo Han
Gastrointestinal
  • 337 Downloads

Abstract

Objective

The differentiation of poorly-differentiated neuroendocrine tumours (PD-NETs), well-differentiated NETs (WD-NETs), and adenocarcinomas (ADCs) is important due to different management options and prognoses. This study is to find the differential CT features of colorectal PD-NETs from WD-NETs and ADCs.

Materials and methods

CT features of 25 colorectal WD-NETs, 36 PD-NETs, and 36 ADCs were retrospectively reviewed. Significant variables were assessed using univariate and multivariate analyses. Receiver operating characteristics analysis determined the optimal cut-off value of tumour and lymph node (LN) size.

Results

Large size, rectum location, ulceroinfiltrative morphology without intact overlying mucosa, heterogeneous attenuation with necrosis, presence of ≥3 enlarged LNs, and metastasis were significant variables to differentiate PD-NETs from WD-NETs (P < 0.05). High attenuation on arterial phase, persistently high enhancement pattern, presence of ≥6 enlarged LNs, large LN size, and wash-in/wash-out enhancement pattern of liver metastasis were significant variables to differentiate PD-NETs from ADCs (P < 0.05).

Conclusions

Compared to WD-NETs, colorectal PD-NETs are usually large, heterogeneous, and ulceroinfiltrative mass without intact overlying mucosa involving enlarged LNs and metastasis. High attenuation on arterial phase, presence of enlarged LNs with larger size and greater number, and wash-in/wash-out enhancement pattern of liver metastasis can be useful CT discriminators of PD-NETs from ADCs.

Key Points

Compared to WD-NETs, PD-NETs more frequently accompany enlarged LNs and metastases.

Metastatic LNs from PD-NETs are significantly larger than those from ADCs.

Hepatic metastases from PD-NETs usually show early enhancement and delayed washout.

Keywords

Colorectum Neuroendocrine tumour Adenocarcinoma CT Differentiation 

Abbreviations

WD-NET

Well-differentiated neuroendocrine tumour

PD-NET

Poorly-differentiated neuroendocrine tumour

ADC

Adenocarcinoma

CT

Computed tomography

LN

Lymph node

ROC

Receiver operating characteristics

AUC

Area under the curve

Notes

Acknowledgements

The scientific guarantor of this publication is Se Hyung Kim, Associate Professor, Department of Radiology, Seoul National University Hospital. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This research was supported by Seoul National University Hospital Research Fund No. 04-2015-620 and was supported by the Basic Science Research Program through the National Research Foundation of Korea [NRF] funded by the Ministry of Science, ICT & Future Planning [NRF-2016R1A2B4007762]. No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board.

Methodology: retrospective, observational, performed at one institution.

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Copyright information

© European Society of Radiology 2017

Authors and Affiliations

  1. 1.Department of RadiologySeoul National University HospitalSeoulKorea
  2. 2.Department of RadiologySeoul National University College of MedicineSeoulKorea
  3. 3.Institute of Radiation MedicineSeoul National University Medical Research CenterSeoulKorea

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