Detection of Functional Homotopy in Traumatic Axonal Injury
This study aimed to explore the interhemispheric intrinsic connectivity in traumatic axonal injury (TAI) patients.
Twenty-one patients with TAI (14 males, seven females; mean age, 38.71 ± 15.25 years) and 22 well-matched healthy controls (16 males, six females; mean age, 38.50 ± 13.82 years) were recruited, and from them we obtained resting-state fMRI data. Interhemispheric coordination was examined using voxel-mirrored homotopic connectivity (VMHC) and seed-based functional connectivity analysis was performed.
We observed significantly decreased VMHC in a number of regions in TAI patients, including the prefrontal, temporal, occipital, parietal, and posterior cingulate cortices, thalami and cerebellar posterior lobes. Subsequent seed-based functional connectivity analysis revealed widely disrupted functional connectivity between the regions of local homotopic connectivity deficits and other areas of the brain, particularly the areas subserving the default, salience, integrative, and executive systems. The lower VMHC of the inferior frontal gyrus and basal ganglia, thalamus, and caudate were significant correlated with the Beck Depression Inventory score, Clinical Dementia Rating score, and Mini-Mental State Examination score, respectively.
TAI is associated with regionally decreased interhemispheric interactions and extensively disrupted seed-based functional connectivity, generating further evidence of diffuse disconnection being associated with clinical symptoms in TAI patients.
• Traumatic axonal injury is associated with decreased interhemispheric connectivity
• Traumatic axonal injury couples with widely disrupted functional connectivity
• These alterations support the default, salience, integrative, and executive functions
KeywordsTraumatic axonal injury Homotopy Interhemispheric connection Brain Resting-state fMRI
Traumatic axonal injury
Traumatic brain injury
Voxel-mirrored homotopic connectivity
Functional magnetic resonance imaging
Mini-Mental State Examination
Disability Rating Scale
Beck Depression Inventory
Motor Assessment Scale
Adaptive Behavior Scale
Hamilton Anxiety Scale
Clinical Dementia Rating
Activity of Daily Living Scale
The scientific guarantor of this publication is Honghan Gong. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This study has received funding by the National Natural Science Foundations of China (81260217 and 81460263). One of the authors (Lei Gao) has significant statistical expertise. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: retrospective, cross sectional study, performed at one institution.
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