European Radiology

, Volume 27, Issue 1, pp 325–335 | Cite as

Detection of Functional Homotopy in Traumatic Axonal Injury

  • Jian Li
  • Lei Gao
  • Kai Xie
  • Jie Zhan
  • Xiaoping Luo
  • Huifang Wang
  • Huifang Zhang
  • Jing Zhao
  • Fuqing Zhou
  • Xianjun Zeng
  • Laichang He
  • Yulin He
  • Honghan Gong
Magnetic Resonance



This study aimed to explore the interhemispheric intrinsic connectivity in traumatic axonal injury (TAI) patients.


Twenty-one patients with TAI (14 males, seven females; mean age, 38.71 ± 15.25 years) and 22 well-matched healthy controls (16 males, six females; mean age, 38.50 ± 13.82 years) were recruited, and from them we obtained resting-state fMRI data. Interhemispheric coordination was examined using voxel-mirrored homotopic connectivity (VMHC) and seed-based functional connectivity analysis was performed.


We observed significantly decreased VMHC in a number of regions in TAI patients, including the prefrontal, temporal, occipital, parietal, and posterior cingulate cortices, thalami and cerebellar posterior lobes. Subsequent seed-based functional connectivity analysis revealed widely disrupted functional connectivity between the regions of local homotopic connectivity deficits and other areas of the brain, particularly the areas subserving the default, salience, integrative, and executive systems. The lower VMHC of the inferior frontal gyrus and basal ganglia, thalamus, and caudate were significant correlated with the Beck Depression Inventory score, Clinical Dementia Rating score, and Mini-Mental State Examination score, respectively.


TAI is associated with regionally decreased interhemispheric interactions and extensively disrupted seed-based functional connectivity, generating further evidence of diffuse disconnection being associated with clinical symptoms in TAI patients.

Key Points

Traumatic axonal injury is associated with decreased interhemispheric connectivity

Traumatic axonal injury couples with widely disrupted functional connectivity

These alterations support the default, salience, integrative, and executive functions


Traumatic axonal injury Homotopy Interhemispheric connection Brain Resting-state fMRI 



Traumatic axonal injury


Traumatic brain injury


Voxel-mirrored homotopic connectivity


Functional magnetic resonance imaging


Functional connectivity


Mini-Mental State Examination


Disability Rating Scale


Beck Depression Inventory


Motor Assessment Scale


Adaptive Behavior Scale


Hamilton Anxiety Scale


Clinical Dementia Rating


Activity of Daily Living Scale



The scientific guarantor of this publication is Honghan Gong. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This study has received funding by the National Natural Science Foundations of China (81260217 and 81460263). One of the authors (Lei Gao) has significant statistical expertise. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: retrospective, cross sectional study, performed at one institution.


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Copyright information

© European Society of Radiology 2016

Authors and Affiliations

  • Jian Li
    • 1
  • Lei Gao
    • 1
  • Kai Xie
    • 1
  • Jie Zhan
    • 1
  • Xiaoping Luo
    • 1
  • Huifang Wang
    • 1
  • Huifang Zhang
    • 1
  • Jing Zhao
    • 1
  • Fuqing Zhou
    • 1
  • Xianjun Zeng
    • 1
  • Laichang He
    • 1
  • Yulin He
    • 1
  • Honghan Gong
    • 1
  1. 1.Department of Radiology, The First Affiliated HospitalNanchang UniversityNanchang CityChina

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