Feasibility of 320-row area detector CT coronary angiography using 40 mL of contrast material: assessment of image quality and diagnostic accuracy
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To assess the image quality and diagnostic accuracy of 320-row area detector CT (320-ADCT) coronary angiography using 40 mL of contrast material in comparison with 60-mL protocol.
This retrospective study included 183 patients who underwent 320-ADCT coronary angiography using 40 mL of contrast and additional 183 sex- and body mass index-matched patients using 60 mL of contrast constituting the control group. Both groups used the same 5-mL/sec injection rate. Quantitative image quality measurements and diagnostic accuracies were calculated and compared.
Mean attenuation and contrast-to-noise ratio (CNR) at the aorta and all coronary arteries were lower in the 40-mL group than in the 60-mL group (all, p < 0.05), except for the CNR at proximal coronary arteries at 100 kVp (p = 0.073). However, the proportion of coronary segments with vessel attenuation >250 HU was not different between groups (all, p > 0.05), except for distal coronary arteries at 80 kVp (p = 0.001). Furthermore, there were no differences in per-patient and per-segment diagnostic accuracies between the groups (all, p > 0.05).
320-ADCT coronary angiography using 40 mL of contrast showed image quality and diagnostic accuracy comparable to the 60-mL protocol, demonstrating the clinical feasibility of lowering the risk of contrast-induced nephropathy through contrast volume reduction.
• 320-ADCT might enable reduction of contrast material volume.
• A 40-mL contrast protocol for 320-ADCT provided acceptable image quality.
• A 40-mL contrast protocol for 320-ADCT demonstrated sufficient diagnostic accuracy.
KeywordsComputed tomography coronary angiography Contrast material Contrast-induced nephropathy 320-row area detector CT Diagnostic accuracy
320-row area detector computed tomography
Body mass index
We would like to acknowledge Ms. Hyunsook Hong from the medical research collaborating center of our institution for her assistance with the statistical analysis. The scientific guarantor of this publication is Jin Wook Chung.
The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. Institutional review board approval was obtained. Written informed consent was waived by the institutional review board. Methodology: retrospective, case-control study, performed at one institution.
- 19.Lim J, Park E-A, Lee W, Shim H, Chung JW (2015) Image quality and radiation reduction of 320-row area detector CT coronary angiography with optimal tube voltage selection and an automatic exposure control system: comparison with body mass index-adapted protocol. Int J Cardiovasc Imaging 31:23–30CrossRefPubMedGoogle Scholar
- 20.Cerqueira MD, Weissman NJ, Dilsizian V et al (2002) Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart a statement for healthcare professionals from the cardiac imaging committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 105:539–542CrossRefPubMedGoogle Scholar
- 35.Zhang LJ, Wang Y, Schoepf UJ et al (2015) Image quality, radiation dose, and diagnostic accuracy of prospectively ECG-triggered high-pitch coronary CT angiography at 70 kVp in a clinical setting: comparison with invasive coronary angiography. Eur Radiol. doi: 10.1007/s00330-015-3868-z Google Scholar