European Radiology

, Volume 26, Issue 12, pp 4570–4576 | Cite as

Magnetic resonance angiography of fetal vasculature at 3.0 T

  • Jaladhar NeelavalliEmail author
  • Uday Krishnamurthy
  • Pavan K. Jella
  • Swati S. Mody
  • Brijesh K. Yadav
  • Kelly Hendershot
  • Edgar Hernandez-Andrade
  • Lami Yeo
  • Maria D. Cabrera
  • Ewart M. Haacke
  • Sonia S. Hassan
  • Roberto Romero
Magnetic Resonance


Magnetic resonance angiography has not been used much previously for visualizing fetal vessels in utero for reasons that include a contraindication for the use of exogenous contrast agents, maternal respiratory motion and fetal motion. In this work, we report the feasibility of using an appropriately modified clinical time-of-flight magnetic resonance imaging sequence for non-contrast angiography of human fetal and placental vessels at 3.0 T. Using this 2D angiography technique, it is possible to visualize fetal vascular networks in late pregnancy.

Key Points

• 3D-visualization of fetal vasculature is feasible using non-contrast MRA at 3.0 T.

• Visualization of placental vasculature is also possible with this method.

• Fetal MRA can serve as a vascular localizer for quantitative MRI studies.

• This method can be extended to 1.5 T.


Non-contrast magnetic resonance angiography Time of flight vascular imaging Placental vasculature Fetal circulation Pseudo-triggering 



The scientific guarantor of this publication is Dr. Jaladhar Neelavalli. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This research was supported, in part, by the Perinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS; by the STTR grant from the NHLBI - 1R42HL112580-01A1); and by Wayne State University’s Perinatology Virtual Discovery Grant to J.N. (made possible by W.K. Kellogg Foundation award P3018205). No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Parts of the data reported in this paper were presented as an abstract at the 25th World Congress on Ultrasound in Obstetrics and Gynecology, 1114 October 2015, Montréal, Quebec, Canada. Methodology: prospective, experimental and performed at one institution.

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Copyright information

© European Society of Radiology 2016

Authors and Affiliations

  • Jaladhar Neelavalli
    • 1
    • 2
    Email author
  • Uday Krishnamurthy
    • 1
    • 2
  • Pavan K. Jella
    • 1
  • Swati S. Mody
    • 1
    • 3
  • Brijesh K. Yadav
    • 1
    • 2
  • Kelly Hendershot
    • 1
  • Edgar Hernandez-Andrade
    • 4
    • 5
  • Lami Yeo
    • 4
    • 5
  • Maria D. Cabrera
    • 1
  • Ewart M. Haacke
    • 1
    • 2
  • Sonia S. Hassan
    • 4
    • 5
  • Roberto Romero
    • 5
    • 6
    • 7
    • 8
  1. 1.Department of RadiologyWayne State University School of MedicineDetroitUSA
  2. 2.Department of Biomedical EngineeringWayne State UniversityDetroitUSA
  3. 3.Department of RadiologyChildren’s Hospital of MichiganDetroitUSA
  4. 4.Department of Obstetrics and GynecologyWayne State UniversityDetroitUSA
  5. 5.Perinatology Research Branch, NICHD/NIH/DHHSBethesda, MD, and DetroitUSA
  6. 6.Department of Obstetrics and GynecologyUniversity of MichiganAnn ArborUSA
  7. 7.Department of Epidemiology and BiostatisticsMichigan State UniversityEast LansingUSA
  8. 8.Center for Molecular Medicine and GeneticsWayne State UniversityDetroitUSA

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