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European Radiology

, Volume 26, Issue 11, pp 3888–3898 | Cite as

Intravoxel incoherent motion MR imaging for breast lesions: comparison and correlation with pharmacokinetic evaluation from dynamic contrast-enhanced MR imaging

  • Chunling Liu
  • Kun Wang
  • Queenie Chan
  • Zaiyi Liu
  • Jine Zhang
  • Hui He
  • Shuixing Zhang
  • Changhong Liang
Breast

Abstract

Objectives

To compare diagnostic performance for breast lesions by quantitative parameters derived from intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and to explore whether correlations exist between these parameters.

Methods

IVIM and DCE MRI were performed on a 1.5-T MRI scanner in patients with suspicious breast lesions. Thirty-six breast cancers and 23 benign lesions were included in the study. Quantitative parameters from IVIM (D, f and D*) and DCE MRI (Ktrans, Kep, Ve and Vp) were calculated and compared between malignant and benign lesions. Spearman correlation test was used to evaluate correlations between them.

Results

D, f, D* from IVIM and Ktrans, Kep, Vp from DCE MRI were statistically different between breast cancers and benign lesions (p < 0.05, respectively) and D demonstrated the largest area under the receiver-operating characteristic curve (AUC = 0.917) and had the highest specificity (83 %). The f value was moderately statistically correlated with Vp (r = 0.692) and had a poor correlation with Ktrans (r = 0.456).

Conclusions

IVIM MRI is useful in the differentiation of breast lesions. Significant correlations were found between perfusion-related parameters from IVIM and DCE MRI. IVIM may be a useful adjunctive tool to standard MRI in diagnosing breast cancer.

Key Points

IVIM provided diffusion as well as perfusion information

IVIM could help differential diagnosis of breast lesions

Correlations were found between perfusion-related parameters from IVIM and DCE MRI

Keywords

Magnetic resonance imaging Diffusion-weighted imaging Intravoxel incoherent motion Breast neoplasm DCE MRI 

Abbreviations

IVIM

Intravoxel incoherent motion

DCE

Dynamic contrast-enhanced

AUC

Area under the curve

AIF

Arterial input function

DWI

Diffusion-weighted imaging

TR

Repetition time

TE

Echo time

FOV

Field of view

FFE

Fast field echo

ICC

Intraclass correlation coefficient

Notes

Acknowledgments

The scientific guarantor of this publication is Changhong Liang. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This study has received funding from the Medical Scientific Research Foundation of Guangdong Province, China (A2012040), the National Scientific Foundation of China (No. 81271596, No. 81271654) and Science and Technology Planning Project of Guangdong Province, China (2014A020212232 and 2012B031800405). Shuixing Zhang kindly provided statistical advice for this manuscript. No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. No study subjects have been previously reported. Methodology: prospective, cross sectional study, performed at one institution.

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Copyright information

© European Society of Radiology 2016

Authors and Affiliations

  • Chunling Liu
    • 1
  • Kun Wang
    • 2
  • Queenie Chan
    • 3
  • Zaiyi Liu
    • 1
  • Jine Zhang
    • 1
  • Hui He
    • 1
  • Shuixing Zhang
    • 1
  • Changhong Liang
    • 1
  1. 1.Department of RadiologyGuangdong General Hospital/Guangdong Academy of Medical SciencesGuangZhouChina
  2. 2.Department of Breast Cancer, Cancer CenterGuangdong General Hospital/Guangdong Academy of Medical SciencesGuangZhouChina
  3. 3.Philips HealthcareHong KongChina

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