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European Radiology

, Volume 26, Issue 11, pp 3865–3873 | Cite as

Preoperative axillary lymph node evaluation in breast cancer patients by breast magnetic resonance imaging (MRI): Can breast MRI exclude advanced nodal disease?

  • Su Jeong Hyun
  • Eun-Kyung Kim
  • Hee Jung Moon
  • Jung Hyun Yoon
  • Min Jung KimEmail author
Breast

Abstract

Objectives

To evaluate the diagnostic performance of breast magnetic resonance imaging (MRI) in preoperative evaluation of axillary lymph node metastasis (ALNM) in breast cancer patients and to assess whether breast MRI can be used to exclude advanced nodal disease.

Methods

A total of 425 patients were included in this study and breast MRI findings were retrospectively reviewed. The diagnostic performance of breast MRI for diagnosis of ALNM was evaluated in all patients, patients with neoadjuvant chemotherapy (NAC), and those without NAC (no-NAC). We evaluated whether negative MRI findings (cN0) can exclude advanced nodal disease (pN2-pN3) using the negative predictive value (NPV) in each group.

Results

The sensitivity and NPV of breast MRI in evaluation of ALNM was 51.3 % (60/117) and 83.3 % (284/341), respectively. For cN0 cases on MRI, pN2-pN3 manifested in 1.8 % (6/341) of the overall patients, 0.4 % (1/257) of the no-NAC group, and 6 % (5/84) of the NAC group. The NPV of negative MRI findings for exclusion of pN2-pN3 was higher for the no-NAC group than for the NAC group (99.6 % vs. 94.0 %, p = 0.039).

Conclusions

Negative MRI findings (cN0) can exclude the presence of advanced nodal disease with an NPV of 99.6 % in the no-NAC group.

Key points

Breast MRI can be used to exclude advanced nodal disease (pN2-3).

Negative MRI allows breast cancer patients to avoid unnecessary axillary surgery (98.2 %).

Negative MRI findings exclude 99.6 % of pN2-pN3 in the no-NAC group.

Negative MRI findings exclude 96.0 % of pN2-pN3 in the NAC group.

Keywords

Magnetic resonance imaging Breast cancer Lymph node Metastasis Axilla 

Abbreviations

MRI

Imagnetic resonance imaging

ALNM

Axillary lymph node metastasis

NAC

Neoadjuvant chemotherapy

NPV

Negative predictive value

SLNB

Sentinel lymph node biopsy

ALND

Axillary lymph node dissection

Notes

Acknowledgement

This study was supported by the Basic Science Research Program of the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning, Republic of Korea (grant 2013R1A1A3013165) and by a faculty research grant of Yonsei University College of Medicine for 2015 (6-2015-0050) and by the Research Institute of Radiological Science, Yonsei University College of Medicine. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Copyright information

© European Society of Radiology 2016

Authors and Affiliations

  • Su Jeong Hyun
    • 1
    • 2
  • Eun-Kyung Kim
    • 1
  • Hee Jung Moon
    • 1
  • Jung Hyun Yoon
    • 1
  • Min Jung Kim
    • 1
    Email author
  1. 1.Department of Radiology, Breast Cancer Clinic, Severance Hospital, Research Institute of Radiological ScienceYonsei University College of MedicineSeoulRepublic of Korea
  2. 2.Department of Radiology, Kangnam Sacred Heart HospitalHallym University Medical CenterSeoulSouth Korea

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