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European Radiology

, Volume 26, Issue 10, pp 3598–3607 | Cite as

Assessment of intracardiac flow and vorticity in the right heart of patients after repair of tetralogy of Fallot by flow-sensitive 4D MRI

  • Daniel Hirtler
  • Julio Garcia
  • Alex J. Barker
  • Julia Geiger
Cardiac

Abstract

Objectives

To comprehensively and quantitatively analyse flow and vorticity in the right heart of patients after repair of tetralogy of Fallot (rTOF) compared with healthy volunteers.

Methods

Time-resolved flow-sensitive 4D MRI was acquired in 24 rTOF patients and 12 volunteers. Qualitative flow evaluation was based on consensus reading of two observers. Quantitative analysis included segmentation of the right atrium (RA) and ventricle (RV) in a four-chamber view to extract volumes and regional haemodynamic information for computation of regional mean and peak vorticity.

Results

Right heart intra-atrial, intraventricular and outflow tract flow patterns differed considerably between rTOF patients and volunteers. Peak RA and mean RV vorticity was significantly higher in patients (p = 0.02/0.05). Significant negative correlations were found between patients’ maximum and mean RV and RA vorticity and ventricular volumes (p < 0.05). The main pulmonary artery (MPA) regurgitant flow was associated with higher RA and RV vorticity, which was significant for RA maximum and RV mean vorticity (p = 0.01/0.03).

Conclusion

The calculation of vorticity based on 4D flow data is an alternative approach to assess intracardiac flow changes in rTOF patients compared with qualitative flow visualization. Alterations in intracardiac vorticity could be relevant with regard to the development of RV dilation and impaired function.

Key points

• 4D flow MRI with vorticity calculation enables a novel approach to assess intracardiac flow.

• Significantly higher intracardiac vorticity occurred in patients after repair of tetralogy of Fallot.

• Regurgitant flow in the main pulmonary artery is associated with higher right heart vorticity.

Keywords

4D flow MRI Tetralogy of Fallot Vorticity Right heart Intracardiac flow 

Notes

Acknowledgement

We thank Bernd Jung, Raoul Arnold and Brigitte Stiller for contributing ideas. The scientific guarantor of this publication is Daniel Hirtler. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study has received funding by the German Academic Exchange Service, project No. 50751442. AJB received support from AHA 13SDG14360004 and NIH K25HL119608. J. Garcia received support from AHA 14POST18350019 and CONACyT (grant 203355). No complex statistical methods were necessary for this paper. Institutional review board approval was obtained. Written informed consent from each participant over 18 years of age and written informed consent from parents or legal guardians for patients under age were obtained prior to MRI examinations. Methodology: prospective, diagnostic and observational study, performed at one institution.

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Copyright information

© European Society of Radiology 2016

Authors and Affiliations

  • Daniel Hirtler
    • 1
  • Julio Garcia
    • 2
  • Alex J. Barker
    • 2
  • Julia Geiger
    • 3
  1. 1.Department of Congenital Heart Defects and Pediatric Cardiology (Heart Center, University of Freiburg)University Hospital FreiburgFreiburgGermany
  2. 2.Department of RadiologyNorthwestern University Feinberg School of MedicineChicagoUSA
  3. 3.Department of RadiologyUniversity Childrens’ Hospital ZurichZurichSwitzerland

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