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European Radiology

, Volume 26, Issue 10, pp 3737–3743 | Cite as

Diffusion measurement of intraplaque hemorrhage and intramural hematoma using diffusion weighted MRI at 3T in cervical artery

  • Bin Yao
  • Li Yang
  • Guangbin Wang
  • Honglu Shi
  • Shanshan Wang
  • Huihua Li
  • Weibo Chen
  • Queenie Chan
Magnetic Resonance

Abstract

Objectives

To assess the difference between carotid haemorrhagic plaque and non-haemorrhagic plaque by using diffusion-weighted imaging (DWI) and to evaluate carotid intraplaque haemorrhage (IPH) and intramural hematoma (IMH) of cervical artery dissection with apparent diffusion coefficient (ADC) measurement.

Methods

Fifty-one symptomatic patients underwent 3.0-T carotid MR imaging, including conventional sequences, three-dimensional (3D) magnetization-prepared rapid acquisition gradient-echo (MPRAGE) sequence, and DWI. Thirty-nine patients with carotid plaque and eight patients with IMH of cervical artery dissection were finally included. The groups of hemorrhagic plaque, non-hemorrhagic plaque and IMH were divided according to 3D MPRAGE sequence. ADC values of different groups were measured, and t tests were performed.

Results

The mean ADC values of hemorrhagic plaques, non-hemorrhagic plaque and IMH were (1.284 ± 0.327) × 10-3mm2/s, (1.766 ± 0.477) × 10-3mm2/s, and (0.563 ± 0.119) × 10-3mm2/s, respectively. The mean ADC values of hemorrhagic and non-hemorrhagic regions in the hemorrhagic plaque group were (0.985 ± 0.376) × 10-3mm2/s and (1.480 ± 0.465) × 10-3mm2/s, respectively. The differences between the hemorrhagic plaque and non-hemorrhagic plaque, hemorrhagic region and non-hemorrhagic region in hemorrhagic plaque, and the hemorrhagic region in the hemorrhagic plaque and IMH of artery dissection were significant (P < 0.05).

Conclusion

DWI may be a useful complement to conventional MR imaging for identifying haemorrhage of carotid plaques and differentiate IMHs from IPH.

Key Points

ADC values of IPH are lower than the plaque without IPH.

DWI might be a useful complement to identify IPH.

IMH may be differentiated from IPH by using DWI.

Keywords

MRI Diffusion-weighted imaging Carotid intraplaque haemorrhage Cervical artery dissection Intramural hematoma ADC 

Abbreviations

ADC

Apparent diffusion coefficient

DWI

Diffusion-weighted imaging

IPH

Intraplaque haemorrhage

IMH

Intramural hematoma

LRNC

Lipid-rich necrotic core

MRA

Magnetic resonance angiography

MRI

Magnetic resonance imaging

MPRAGE

Magnetization-prepared rapid acquisition gradient-echo

3D

Three-dimensional

Notes

Acknowledgments

The scientific guarantor of this publication is Guangbin Wang. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding.

No complex statistical methods were necessary for this paper. Institutional review board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective, experimental, performed at one institution.

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Copyright information

© European Society of Radiology 2015

Authors and Affiliations

  • Bin Yao
    • 1
  • Li Yang
    • 2
  • Guangbin Wang
    • 3
  • Honglu Shi
    • 3
  • Shanshan Wang
    • 3
  • Huihua Li
    • 3
  • Weibo Chen
    • 4
  • Queenie Chan
    • 4
  1. 1.The Second Affiliated Hospital of Nanchang UniversityNanchangChina
  2. 2.Department of Radiology, Shanghai Institute of Medical Imaging, Zhongshan HospitalFudan UniversityShanghaiPeople’s Republic of China
  3. 3.Shandong Medical Imaging Research InstituteShandong UniversityJinanPeople’s Republic of China
  4. 4.Philips HealthcareShanghaiPeople’s Republic of China

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