Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease
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We used neurite orientation dispersion and density imaging (NODDI) to quantify changes in the substantia nigra pars compacta (SNpc) and striatum in Parkinson disease (PD).
Diffusion-weighted magnetic resonance images were acquired from 58 PD patients and 36 age- and sex-matched controls. The intracellular volume fraction (Vic), orientation dispersion index (OD), and isotropic volume fraction (Viso) of the basal ganglia were compared between groups. Multivariate logistic regression analysis determined which diffusion parameters were independent predictors of PD. Receiver operating characteristic (ROC) analysis compared the diagnostic accuracies of the evaluated indices. Pearson coefficient analysis correlated each diffusional parameter with disease severity.
Vic in the contralateral SNpc and putamen were significantly lower in PD patients than in healthy controls (P < 0.00058). Vic and OD in the SNpc and putamen showed significant negative correlations (P < 0.05) with disease severity. Multivariate logistic analysis revealed that Vic (P = 0.0000046) and mean diffusivity (P = 0.019) in the contralateral SNpc were the independent predictors of PD. In the ROC analysis, Vic in the contralateral SNpc showed the best diagnostic performance (mean cutoff, 0.62; sensitivity, 0.88; specificity, 0.83).
NODDI is likely to be useful for diagnosing PD and assessing its progression.
• Neurite orientation dispersion and density imaging (NODDI) is a new diffusion MRI technique
• NODDI estimates neurite microstructure more specifically than diffusion tensor imaging
• By using NODDI, nigrostriatal alterations in PD can be evaluated in vivo
• NOODI is useful for diagnosing PD and assessing its disease progression
KeywordsBasal ganglia Diffusion MRI Neurodegenerative disorders Parkinson disease Substantia nigra pars compacta
Diffusion tensor imaging
Neurite orientation dispersion and density imaging
Orientation dispersion index
Receiver operating characteristic
Regions of interest
Substantia nigra pars compacta
Intracellular volume fraction
Isotropic volume fraction
The scientific guarantor of this publication is Shigeki Aoki. The authors of this manuscript declare no relationships with any companies of which the products or services may be related to the subject matter of the article. This study has received funding by a Grant-in-Aid for Scientific Research on Innovative Areas (Comprehensive Brain Science Network) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan and by MEXT/JSPS KAKENHI Grant Number 24591787. One of the authors has significant statistical expertise. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. No study subjects or cohorts have been previously reported. Methodology: prospective, case-control study, performed at one institution.
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