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European Radiology

, Volume 26, Issue 8, pp 2685–2696 | Cite as

Prenatal MR imaging features of isolated cerebellar haemorrhagic lesions

  • Francesca Martino
  • Mariya MalovaEmail author
  • Claudia Cesaretti
  • Cecilia Parazzini
  • Chiara Doneda
  • Luca A. Ramenghi
  • Andrea Rossi
  • Andrea Righini
Magnetic Resonance

Abstract

Objective

Prenatal features of isolated cerebellar haemorrhagic lesions have not been sufficiently characterised. We aimed to better define their MR imaging characteristics, documenting the location, extension, evolution stage and anatomic sequelae, and to better understand cerebellar haemorrhage pathophysiology.

Materials and methods

We screened our foetal MR imaging database (3200 cases) for reports of haemorrhagic lesions affecting only the cerebellum (without any supratentorial bleeding or other clastic lesions), defined as one of the following: T2-weighted hypointense or mixed hypo-/hyperintense signal; rim of T2-weighted hypointense signal covering the surface of volume-reduced parenchyma; T1-weighted hyperintense signal; increased DWI signal.

Results

Seventeen cases corresponded to the selection criteria. All lesions occurred before the 26th week of gestation, with prevalent origin from the peripheral-caudal portion of the hemispheres and equal frequency of unilateral/bilateral involvement. The caudal vermis appeared affected in 2/3 of cases, not in all cases confirmed postnatally. Lesions evolved towards malformed cerebellar foliation. The aetiology and pathophysiology were unknown, although in a subset of cases intra- and extracranial venous engorgement seemed to play a key role.

Conclusions

Onset from the peripheral and caudal portion of the hemispheres seems characteristic of prenatal cerebellar haemorrhagic lesions. Elective involvement of the peripheral germinal matrix is hypothesised.

Key Points

• The cerebellum can be vulnerable to bleeding during foetal development.

• Isolated cerebellar haemorrhages can be seen on prenatal MRI.

• In our cohort, isolated foetal cerebellar haemorrhages occurred before the 26th gestational week.

• Haemorrhagic lesions happening in utero could look like malformations on post-natal MRI.

• Venous engorgement could have a role in causing cerebellar haemorrhagic lesions.

Keywords

Prenatal diagnosis Magnetic resonance imaging Cerebellum Haemorrhage Cerebellar cortex 

Abbreviations

MR

Magnetic resonance

DWI

Diffusion-weighted imaging

Notes

Acknowledgments

The scientific guarantor of this publication is Andrea Righini, M.D. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. No complex statistical methods were necessary for this article. Institutional Review Board approval was not required because this retrospective study complied with internal clinical review study guidelines in use in our institution. Written informed consent was not required for this study because all mothers signed a disclosure form allowing their clinical data to be used for clinical retrospective research. Methodology: retrospective, observational, single-centre study.

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Copyright information

© European Society of Radiology 2015

Authors and Affiliations

  • Francesca Martino
    • 1
  • Mariya Malova
    • 2
    Email author
  • Claudia Cesaretti
    • 3
  • Cecilia Parazzini
    • 3
  • Chiara Doneda
    • 3
  • Luca A. Ramenghi
    • 2
  • Andrea Rossi
    • 4
  • Andrea Righini
    • 3
  1. 1.Radiology DepartmentOspedale Maggiore della CaritàNovaraItaly
  2. 2.Neonatal Intensive Care UnitIstituto Giannina GasliniGenoaItaly
  3. 3.Radiology and Neuroradiology DepartmentV. Buzzi Children’s HospitalMilanItaly
  4. 4.Neuroradiology UnitIstituto Giannina GasliniGenoaItaly

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