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European Radiology

, Volume 26, Issue 7, pp 1981–1990 | Cite as

Portal hypertension in patients with cirrhosis: indirect assessment of hepatic venous pressure gradient by measuring azygos flow with 2D-cine phase-contrast magnetic resonance imaging

  • Hervé GouyaEmail author
  • Sophie Grabar
  • Olivier Vignaux
  • Anastasia Saade
  • Stanislas Pol
  • Paul Legmann
  • Philippe Sogni
Magnetic Resonance

Abstract

Objectives

To measure azygos, portal and aortic flow by two-dimensional cine phase-contrast magnetic resonance imaging (2D-cine PC MRI), and to compare the MRI values to hepatic venous pressure gradient (HVPG) measurements, in patients with cirrhosis.

Methods

Sixty-nine patients with cirrhosis were prospectively included. All patients underwent HVPG measurements, upper gastrointestinal endoscopy and 2D-cine PC MRI measurements of azygos, portal and aortic blood flow. Univariate and multivariate regression analyses were used to evaluate the correlation between the blood flow and HVPG. The performance of 2D-cine PC MRI to diagnose severe portal hypertension (HVPG ≥ 16 mmHg) was determined by receiver operating characteristic curve (ROC) analysis, and area under the curves (AUC) were compared.

Results

Azygos and aortic flow values were associated with HVPG in univariate linear regression model. Azygos flow (p < 10-3), aortic flow (p = 0.001), age (p = 0.001) and presence of varices (p < 10-3) were independently associated with HVPG. Azygos flow (AUC = 0.96 (95 % CI [0.91–1.00]) had significantly higher AUC than aortic (AUC = 0.64 (95 % CI [0.51–0.77]) or portal blood flow (AUC = 0.40 (95 % CI [0.25–0.54]).

Conclusions

2D-cine PC MRI is a promising technique to evaluate significant portal hypertension in patients with cirrhosis.

Key Points

Noninvasive HVPG assessment can be performed with MRI azygos flow.

Azygos MRI flow is an easy-to-measure marker to detect significant portal hypertension.

MRI flow is more specific that varice grade to detect portal hypertension.

Keywords

Magnetic resonance imaging Azygos vein Flow Portal hypertension Liver 

Abbreviations

MRI

Magnetic resonance imaging

HVPG

Hepatic venous pressure gradient

UGE

Upper gastrointestinal endoscopy

IQR

Interquartile range

ROC

Receiver operating characteristic

AUC

Area under the curve

Notes

Acknowledgments

The scientific guarantor of this publication is Hervé Gouya. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. One of the authors has significant statistical expertise. Sophie Grabar, Biostatistics and Epidemiology Unit, Hotel-Dieu and Paris-Descartes University, Assistance Publique-Hôpitaux de Paris, Paris, France. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. This is not a study on animals. Study subjects have never been previously reported.

Methodology: prospective, diagnostic or prognostic study, performed at one institution.

Supplementary material

330_2015_3991_MOESM1_ESM.docx (87 kb)
Supplementary material 1 (DOCX 86 kb)
330_2015_3991_MOESM2_ESM.docx (14 kb)
Supplementary material 2 (DOCX 14 kb)

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Copyright information

© European Society of Radiology 2015

Authors and Affiliations

  • Hervé Gouya
    • 1
    Email author
  • Sophie Grabar
    • 2
  • Olivier Vignaux
    • 1
  • Anastasia Saade
    • 1
  • Stanislas Pol
    • 3
  • Paul Legmann
    • 1
  • Philippe Sogni
    • 3
  1. 1.Department of Radiology, Hôpital Cochin and Paris-Descartes UniversityAssistance Publique-Hôpitaux de ParisParisFrance
  2. 2.Biostatistics and Epidemiology Unit, Hotel-Dieu and Paris-Descartes University, Hôpital CochinAssistance Publique-Hôpitaux de ParisParisFrance
  3. 3.Liver Unit, Hôpital Cochin and Inserm U-1016, Paris-Descartes UniversityAssistance Publique-Hôpitaux de ParisParisFrance

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