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European Radiology

, Volume 26, Issue 6, pp 1921–1928 | Cite as

Accelerated magnetic resonance diffusion tensor imaging of the median nerve using simultaneous multi-slice echo planar imaging with blipped CAIPIRINHA

  • Lukas FilliEmail author
  • Marco Piccirelli
  • David Kenkel
  • Andreas Boss
  • Andrei Manoliu
  • Gustav Andreisek
  • Himanshu Bhat
  • Val M. Runge
  • Roman Guggenberger
Magnetic Resonance

Abstract

Purpose

To investigate the feasibility of MR diffusion tensor imaging (DTI) of the median nerve using simultaneous multi-slice echo planar imaging (EPI) with blipped CAIPIRINHA.

Materials and methods

After federal ethics board approval, MR imaging of the median nerves of eight healthy volunteers (mean age, 29.4 years; range, 25–32) was performed at 3 T using a 16-channel hand/wrist coil. An EPI sequence (b-value, 1,000 s/mm2; 20 gradient directions) was acquired without acceleration as well as with twofold and threefold slice acceleration. Fractional anisotropy (FA), mean diffusivity (MD) and quality of nerve tractography (number of tracks, average track length, track homogeneity, anatomical accuracy) were compared between the acquisitions using multivariate ANOVA and the Kruskal-Wallis test.

Results

Acquisition time was 6:08 min for standard DTI, 3:38 min for twofold and 2:31 min for threefold acceleration. No differences were found regarding FA (standard DTI: 0.620 ± 0.058; twofold acceleration: 0.642 ± 0.058; threefold acceleration: 0.644 ± 0.061; p ≥ 0.217) and MD (standard DTI: 1.076 ± 0.080 mm2/s; twofold acceleration: 1.016 ± 0.123 mm2/s; threefold acceleration: 0.979 ± 0.153 mm2/s; p ≥ 0.074). Twofold acceleration yielded similar tractography quality compared to standard DTI (p > 0.05). With threefold acceleration, however, average track length and track homogeneity decreased (p = 0.004–0.021).

Conclusion

Accelerated DTI of the median nerve is feasible. Twofold acceleration yields similar results to standard DTI.

Key Points

Standard DTI of the median nerve is limited by its long acquisition time.

Simultaneous multi-slice acquisition is a new technique for accelerated DTI.

Accelerated DTI of the median nerve yields similar results to standard DTI.

Keywords

Diffusion tensor imaging Diffusion tractography Simultaneous multi-slice Echo-planar imaging Median nerve 

Abbreviations

CAIPIRINHA

Controlled aliasing in parallel imaging results in higher acceleration

DRUJ

Distal radio-ulnar joint

DTI

Diffusion tensor imaging

EPI

Echo planar imaging

FA

Fractional anisotropy

FDi

Fibre density index

ICC

Intra-class correlation coefficient

MD

Mean diffusivity

ROI

Region of interest

SMS

Simultaneous multi-slice acquisition

SNR

Signal-to-noise ratio

TE

Echo time

TR

Repetition time

Notes

Acknowledgments

The authors kindly thank Heiko Meyer and Thomas Beck (both Siemens Healthcare, Erlangen, Germany) for providing them with the software for simultaneous multi-slice acquisition. The scientific guarantor of this publication is Roman Guggenberger, MD. Gustav Andreisek, MD, MBA, and Val M. Runge, MD, declare relationships with Siemens Healthcare, Erlangen, Germany. Himanshu Bhat, PhD is an employee of Siemens Medical Solutions USA Inc, Charlestown, MA, United States. These companies had no influence on the present study. The authors state that this work has not received any funding. No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects in this study. Methodology: prospective, experimental, performed at one institution.

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Copyright information

© European Society of Radiology 2015

Authors and Affiliations

  • Lukas Filli
    • 1
    Email author
  • Marco Piccirelli
    • 2
  • David Kenkel
    • 1
  • Andreas Boss
    • 1
  • Andrei Manoliu
    • 1
  • Gustav Andreisek
    • 1
  • Himanshu Bhat
    • 3
  • Val M. Runge
    • 1
  • Roman Guggenberger
    • 1
  1. 1.Institute of Diagnostic and Interventional RadiologyUniversity Hospital of Zurich, University of ZurichZurichSwitzerland
  2. 2.Department of NeuroradiologyUniversity Hospital of ZurichZurichSwitzerland
  3. 3.Siemens Medical Solutions USA IncCharlestownUSA

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