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European Radiology

, Volume 26, Issue 6, pp 1818–1825 | Cite as

Comparison of contrast-enhanced modified T1-weighted 3D TSE black-blood and 3D MP-RAGE sequences for the detection of cerebral metastases and brain tumours

  • N. N. Kammer
  • E. Coppenrath
  • K. M. Treitl
  • H. Kooijman
  • O. Dietrich
  • T. Saam
Oncology

Abstract

Objectives

To compare a modified T1-weighted 3D TSE black-blood sequence with sub-millimetre resolution (T1-mVISTA) with a magnetization-prepared rapid gradient echo (MP-RAGE) sequence for the diagnosis of cerebral malignomas.

Methods

Forty-six patients with known or suspected intracranial tumours and 15 control patients were included in this retrospective study. All patients underwent T1-mVISTA (0.75-mm isotropic resolution, 4:43 min) and MP-RAGE (0.8-mm isotropic resolution, 4:46 minutes) at 3-Tesla in random order after application of contrast agent. Two experienced radiologists determined the number of lesions. Maximum diameter, diagnostic confidence (DC), visual assessment of contrast enhancement (VCE) and CNRlesion/parenchyma were assessed for each lesion.

Results

Significantly more lesions were detected with T1-mVISTA compared to the MP-RAGE (61 vs. 36; p < 0.05). Further, DC and VCE was rated significantly higher in the T1-mVISTA (p < 0.05 and p < 0.001). Mean CNRlesion/parenchyma was twofold higher for T1-mVISTA (24.2 ± 17.5 vs. 12.7 ± 11.5, p < 0.001). The 25 lesions detected only in T1-mVISTA were significantly smaller than those detected in both sequences (4.3 ± 3.7 mm vs. 11.3 ± 10.7 mm; p < 0.01).

Conclusions

T1-mVISTA increases the contrast of lesions significantly compared to MP-RAGE and might therefore improve detection rates of small lesions in early stages of disease.

Key points

• T1-mVISTA leads to significantly higher contrast-to-noise ratios of cerebral malignomas.

• T1-mVISTA detects significantly more metastatic lesions compared to 3D-MPRAGE.

• Lesions detected only by T1-mVISTA are smaller than those detected in both sequences.

• Diagnostic confidence is significantly higher for lesions detected by T1-mVISTA.

• Application of T1-mVISTA might be of high relevance in early stages of disease.

Keywords

Magnetic resonance imaging 3-D imaging Brain imaging Clinical oncology Neoplastic processes 

Abbreviations and acronyms

2D

Two-dimensional

3D

Three-dimensional

BB

Black-blood

CE

Contrast-enhanced

CNR

Contrast-to-noise ratio

DC

Diagnostic confidence

DWI

Diffusion-weighted imaging

ETL

Echo train length

FA

Flip angles

FLAIR

Fluid attenuated inversion recovery

GRE

Gradient echo

MP-RAGE

Magnetization prepared rapid gradient echo

MRI

Magnetic resonance imaging

Ms

Milliseconds

MSDE

Motion-sensitized driven-equilibrium

MT

Magnetization transfer

Mvista

Modified Volumetric isotropic TSE Acquisition

ROC

Receiver operating characteristic

ROI

Region of interest

SE

Spin echo

SI

Signal intensity

SPACE

Sampling Perfection with Application optimized Contrasts using different flip angle Evolution

T

Tesla

TE

Time to echo

TR

Time of repetition

TSE

Turbo spin echo

T1w

T1-weighted

T2w

T2-weighted

VCE

Visual assessment of contrast enhancement

VFA

Variable flip angles

Notes

Acknowledgments

The scientific guarantor of this publication is Nora Navina Kammer. The authors of this manuscript declare relationships with the following companies: Dr. Hendrik Kooijman is employee of Philips Healthcare. The authors state that this work has not received any funding. No complex statistical methods were necessary for this paper. Institutional Review Board approval was not required because a waiver was obtained. Written informed consent was waived by the Institutional Review Board.

Methodology: diagnostic or prognostic study, performed at one institution.

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Copyright information

© European Society of Radiology 2015

Authors and Affiliations

  • N. N. Kammer
    • 1
  • E. Coppenrath
    • 1
  • K. M. Treitl
    • 1
  • H. Kooijman
    • 2
  • O. Dietrich
    • 3
  • T. Saam
    • 1
  1. 1.Institute for Clinical RadiologyLudwig-Maximilians-University Hospital MunichMunichGermany
  2. 2.Philips HealthcareHamburgGermany
  3. 3.Josef Lissner Laboratory for Biomedical Imaging, Institute for Clinical RadiologyLudwig-Maximilians-University Hospital MunichMunichGermany

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