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European Radiology

, Volume 25, Issue 11, pp 3247–3254 | Cite as

Perfusion imaging of parotid gland tumours: usefulness of arterial spin labeling for differentiating Warthin’s tumours

  • Hiroki Kato
  • Masayuki Kanematsu
  • Haruo Watanabe
  • Kimihiro Kajita
  • Keisuke Mizuta
  • Mitsuhiro Aoki
  • Tomoyuki Okuaki
Head and Neck

Abstract

Objective

To assess prospectively the efficacy of arterial spin labelling (ASL) against conventional and diffusion-weighted (DW) MR imaging for differentiating parotid gland tumours.

Methods

We included 10 pleomorphic adenomas, 12 Warthin's tumours, and nine malignant tumours of the parotid glands. Only tumours larger than 10 mm were included in this study. All parotid gland tumours underwent T1-weighted, T2-weighted, DW, and ASL imaging. Tumour-to-parotid gland signal intensity ratios (SIRs) and apparent diffusion coefficients (ADCs) of solid components were correlated with these pathologies.

Results

SIRs on T2-weighted images and ADCs were higher in pleomorphic adenomas than in Warthin's tumours (p < .01) and malignant tumours (p < .01). SIRs on ASL were higher in Warthin's tumours than in pleomorphic adenomas (p < .01) and malignant tumours (p < .05). Az value of SIRs on ASL for differentiating Warthin's tumours from the other pathologies was 0.982. The sensitivity, specificity, and accuracy of SIRs on ASL for the diagnosis of Warthin's tumours at an optimal SIR threshold of over 8.70 were 91.7 %, 94.7 %, and 93.5 %, respectively.

Conclusions

ASL with SIR measurements could non-invasively evaluate tumour blood flow of parotid gland tumours and differentiate Warthin's tumours from pleomorphic adenomas and malignant tumours.

Key Points

ASL non-invasively evaluates tumour blood flow of parotid gland tumours

ASL differentiates Warthin's tumours from pleomorphic adenomas and malignant tumours

ASL cannot differentiate between pleomorphic adenomas and malignant tumours

Keywords

Arterial spin labelling Diffusion-weighted imaging Parotid gland Salivary gland tumour Warthin’s tumour 

Notes

Acknowledgments

The scientific guarantor of this publication is Hiroki Kato. Tomoyuki Okuaki is employee of Philips Healthcare. The other authors of this manuscript declare no relationships with any companies. The authors state that this work has not received any funding. No complex statistical methods were necessary for this paper. Institutional review board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. No study subjects or cohorts have been previously reported. Methodology: retrospective, diagnostic or prognostic study, performed at one institution.

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Copyright information

© European Society of Radiology 2015

Authors and Affiliations

  • Hiroki Kato
    • 1
  • Masayuki Kanematsu
    • 1
    • 2
  • Haruo Watanabe
    • 1
  • Kimihiro Kajita
    • 2
  • Keisuke Mizuta
    • 3
  • Mitsuhiro Aoki
    • 3
  • Tomoyuki Okuaki
    • 4
  1. 1.Department of RadiologyGifu University School of MedicineGifuJapan
  2. 2.High-level Imaging Diagnosis CenterGifu University HospitalGifuJapan
  3. 3.Department of OtolaryngologyGifu University School of MedicineGifuJapan
  4. 4.Philips HealthcareTokyoJapan

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