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European Radiology

, Volume 25, Issue 9, pp 2688–2692 | Cite as

Ultrasound evaluation of joints in systemic lupus erythematosus: a systematic review

  • Carolina F. Lins
  • Mittermayer B. SantiagoEmail author
Ultrasound

Abstract

Objectives

The aim of this systematic review is to describe the scientific evidence regarding sonographic findings of joints in SLE patients.

Methods

Seven databases were searched (PubMed, ScienceDirect, Scopus, Cochrane, EMBASE, LILACS, and SciELO) for articles from 1950 to January 2015. The keywords used for selecting articles include “lupus”, “ultrasound imaging”, “ultrasonography”, “synovitis”, “tenosynovitis”, and “arthritis”.

Results

A total of 12 articles were included in the final analysis. In total, 610 SLE patients and 1,091 joints were studied. Most patients underwent bilateral joint examination by US. A total of 888 hands and wrists, 154 ankles/feet, and 56 knees were examined. Effusion was identified in 602 joints, synovitis in 213, tenosynovitis in 210, synovial hypertrophy in 150, and bone erosions in 73 cases. The majority of the studies demonstrated higher frequency of musculoskeletal abnormalities on US than those observed on physical examination.

Conclusion

US seems to be a valuable tool to identify subclinical joint manifestations in SLE. Prospective studies are necessary to determine if those patients with subclinical joint abnormalities have a higher risk for the development of chronic deformities as those seen in Jaccoud’s Arthropathy.

Key Points

Musculoskeletal involvement occurs in more than 90 % of SLE cases.

Arthralgia or tender/swollen joints found on physical examination showed more US findings.

Patients without joint symptoms or physical examinations changes showed musculoskeletal sonographic findings.

US became a useful tool for rheumatologists.

A substantial number of asymptomatic patients show abnormalities at musculoskeletal US.

Keywords

Ultrasound Systemic lupus erythematosus Systematic review Joints Synovitis 

Notes

Acknowledgments

The scientific guarantor of this publication is Mittermayer Barreto Santiago M.D., PhD. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. No complex statistical methods were necessary for this paper. Institutional review board approval was not required because the article is a systematic review.

M.S. received a scholarship from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

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Copyright information

© European Society of Radiology 2015

Authors and Affiliations

  1. 1.Escola Bahiana de Medicina e Saúde PúblicaSalvadorBrazil
  2. 2.Serviços Especializados em Reumatologia da BahiaSalvadorBrazil

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