Non-invasive biomechanical characterization of intervertebral discs by shear wave ultrasound elastography: a feasibility study
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Although magnetic resonance is widely spread to assess qualitatively disc morphology, a simple method to determine reliably intervertebral disc status is still lacking. Shear wave elastography is a novel technique that allows quantitative evaluation of soft-tissues’ mechanical properties. The aim of this study was to assess preliminary the feasibility and reliability of mechanical characterization of cervical intervertebral discs by elastography and to provide first reference values for asymptomatic subjects.
Elastographic measurements were performed to determine shear wave speed (SWS) in C6-C7 or C7-T1 disc of 47 subjects; repeatability and inter-operator reproducibility were assessed.
Global average shear wave speed (SWS) was 3.0 ± 0.4 m/s; measurement repeatability and inter-user reproducibility were 7 and 10 %, respectively. SWS was correlated with both subject’s age (p = 1.3 × 10−5) and body mass index (p = 0.008).
Shear wave elastography in intervertebral discs proved reliable and allowed stratification of subjects according to age and BMI. Applications could be relevant, for instance, in early detection of disc degeneration or in follow-up after trauma; these results open the way to larger cohort studies to define the place of this technique in routine intervertebral disc assessment.
• A simple method to obtain objectively intervertebral disc status is still lacking
• Shear wave elastography was applied in vivo to assess intervertebral discs
• Elastography showed promising results in biomechanical disc evaluation
• Elastography could be relevant in clinical routine for intervertebral disc assessment
KeywordsSpine Spinal diseases Fibrocartilage Tissue elasticity imaging Biomechanics
The scientific guarantor of this publication is Prof. Wafa Skalli, Arts et Métiers ParisTech, LBM, 151 bd de l'hôpital, 75013 Paris. Jean-Luc Gennisson is a scientific consultant for SuperSonic Imagine, and Mickael Tanter is cofounder and shareholder of SuperSonic Imagine (Aix-en-Provence, France). The other authors declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors are grateful to the ParisTech BiomecAM chair program on subject-specific musculoskeletal modelling for funding (with the support of ParisTech and Yves Cotrel Foundations, Société Générale, Proteor and Covea). No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained (ethical committee approval CPP Ile-de-France VI 6036). Written informed consent was obtained from all subjects (patients) in this study. Some study subjects or cohorts have been previously reported in congress communications. Methodology: prospective, experimental, performed at one institution.
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