Does secretin stimulation add to magnetic resonance cholangiopancreatography in characterising pancreatic cystic lesions as side-branch intraductal papillary mucinous neoplasm?
- 385 Downloads
To assess the value of secretin during magnetic resonance cholangiopancreatography (MRCP) in demonstrating communication between cystic lesions and the pancreatic duct to help determine the diagnosis of side-branch intraductal papillary mucinous neoplasm (SB-IPMN).
This is an IRB-approved, HIPAA-compliant retrospective study of 29 SB-IPMN patients and 13 non-IPMN subjects (control) who underwent secretin-enhanced MRCP (s-MRCP). Two readers blinded to the final diagnosis reviewed three randomised image sets: (1) pre-secretin HASTE, (2) dynamic s-MRCP and (3) post-secretin HASTE. Logistic regression, generalised linear models and ROC analyses were used to compare pre- and post-secretin results.
There was no significant difference in median scores for the pre-secretin [reader 1: 1; reader 2: 2 (range -2 to 2)] and post-secretin HASTE [reader 1: 1; reader 2: 1 (range -2 to 2)] in the SB-IPMN group (P = 0.14), while the scores were lower for s-MRCP [reader 1: 0.5 (range -2 to 2); reader 2: 0 (range -1 to 2); P = 0.016]. There was no significant difference in mean maximum diameter of SB-IPMN on pre- and post-secretin HASTE, and s-MRCP (P > 0.05).
Secretin stimulation did not add to MRCP in characterising pancreatic cystic lesions as SB-IPMN.
• Magnetic resonance cholangiopancreatography (MRCP) is used to evaluate pancreatic cystic lesions.
• Intraductal papillary mucinous neoplasm (IPMN) is a type of pancreatic cystic neoplasm.
• Secretin administration does not facilitate the diagnosis of IPMN on MRCP.
KeywordsMagnetic resonance imaging Secretin Pancreatic neoplasms Intraductal papillary mucinous neoplasm Pancreatic cyst
magnetic resonance cholangiopancreatography
secretin-enhanced magnetic cholangiopancreatography
intraductal papillary mucinous neoplasm, SB-IPMN, side-branch intraductal papillary mucinous neoplasm
multidetector computed tomography
half-Fourier acquisition single-shot turbo spin-echo
main pancreatic duct
The scientific guarantor of this publication is Namita S. Gandhi, MD. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. One of the authors has significant statistical expertise. Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board. Methodology: retrospective, diagnostic, performed at one institution
- 2.Kloppel G, Solcia E, Longnecker DS, Capella C, Sobin LH (1996) Histological typing of tumours of the exocrine pancreas. In: World Health Organization International Histological Classification of Tumors, 2nd edn. Springer, Berlin, pp 11–20Google Scholar