Dynamic Contrast-Enhanced MR Imaging of Endometrial Cancer: Optimizing the Imaging Delay for Tumour-Myometrium Contrast
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To investigate the optimal imaging delay time of dynamic contrast-enhanced magnetic resonance (MR) imaging in women with endometrial cancer.
Materials and Methods
This prospective single-institution study was approved by the institutional review board, and informed consent was obtained from the participants. Thirty-five women (mean age, 54 years; age range, 29–66 years) underwent dynamic contrast-enhanced MR imaging with a temporal resolution of 25–40 seconds. The signal intensity difference ratios between the myometrium and endometrial cancer were analyzed to investigate the optimal imaging delay time using single change-point analysis.
The optimal imaging delay time for appropriate tumour-myometrium contrast ranged from 31.7 to 268.1 seconds. The median optimal imaging delay time was 91.3 seconds, with an interquartile range of 46.2 to 119.5 seconds. The median signal intensity difference ratios between the myometrium and endometrial cancer were 0.03, with an interquartile range of -0.01 to 0.06, on the pre-contrast MR imaging and 0.20, with an interquartile range of 0.15 to 0.25, on the post-contrast MR imaging.
An imaging delay of approximately 90 seconds after initiating contrast material injection may be optimal for obtaining appropriate tumour-myometrium contrast in women with endometrial cancer.
• Recent advances have allowed for MR imaging of high temporal resolution.
• Contrast-enhanced MR imaging is helpful for evaluation of endometrial cancer.
• An imaging delay of 90 seconds may be optimal.
KeywordsMR Gadolinium K-space Uterine neoplasms Staging
This study was supported by the research fund of the Radiological Research Foundation of Korea (2011-03), and we thank Chun Ho Kang, who participated in the acquisition of MR images. The scientific guarantor of this publication is Dr. Min Hoan Moon. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. One of the authors has significant statistical expertise. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective observational study, performed at one institution.
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