European Radiology

, Volume 24, Issue 9, pp 2236–2244 | Cite as

Feasibility study of CT perfusion imaging for prostate carcinoma

  • Nesat Cullu
  • Mecit KantarciEmail author
  • Hayri Ogul
  • Senol Adanur
  • Aylin Okur
  • Erdem Koc
  • Berhan Pirimoglu
  • Leyla Karaca
  • Yesim Kizrak
  • Ozkan Polat



The aim of this feasibility study was to obtain initial data with which to assess the efficiency of perfusion CT imaging (CTpI) and to compare this with magnetic resonance imaging (MRI) in the diagnosis of prostate carcinoma.

Materials and methods

This prospective study involved 25 patients with prostate carcinoma undergoing MRI and CTpI. All analyses were performed on T2-weighted images (T2WI), apparent diffusion coefficient (ADC) maps, diffusion-weighted images (DWI) and CTp images. We compared the performance of T2WI combined with DWI and CTp alone. The study was approved by the local ethics committee, and written informed consent was obtained from all patients.


Tumours were present in 87 areas according to the histopathological results. The diagnostic performance of the T2WI+DWI+CTpI combination was significantly better than that of T2WI alone for prostate carcinoma (P < 0.001). The diagnostic value of CTpI was similar to that of T2WI+DWI in combination. There were statistically significant differences in the blood flow and permeability surface values between prostate carcinoma and background prostate on CTp images.


CTp may be a valuable tool for detecting prostate carcinoma and may be preferred in cases where MRI is contraindicated. If this technique is combined with T2WI and DWI, its diagnostic value is enhanced.

Key Points

Perfusion CT is a helpful technique for prostate carcinoma diagnosis.

Colour maps allow easy and rapid visual assessment of the functional changes.

Colour maps of prostate carcinoma provide information about in vivo tumoral vascularity.

CTp images may be added into routine radiological examinations.

CTp provides guidance for histopathological correlation if biopsy is scheduled.


Prostate Carcinoma Magnetic resonance imaging Computed tomography Perfusion 



apparent diffusion coefficient


blood flow


blood volume


computed tomography perfusion


diffusion weighted imaging


microvessel density


permeability surface



The scientific guarantor of this publication is Mecit Kantarci. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. No complex statistical methods were necessary for this paper. Institutional review board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Written informed consent was waived by the institutional review board. Methodology: prospective, diagnostic study, performed at one institution.

Conflict of interest

We have declared that there is no conflict of interest.


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Copyright information

© European Society of Radiology 2014

Authors and Affiliations

  • Nesat Cullu
    • 1
    • 2
  • Mecit Kantarci
    • 2
    Email author
  • Hayri Ogul
    • 2
  • Senol Adanur
    • 3
  • Aylin Okur
    • 2
    • 4
  • Erdem Koc
    • 3
  • Berhan Pirimoglu
    • 2
  • Leyla Karaca
    • 2
  • Yesim Kizrak
    • 2
  • Ozkan Polat
    • 3
  1. 1.Department of RadiologyMuğla Sıtkı Koçman University, School of MedicineMuğlaTurkey
  2. 2.Department of RadiologyAtatürk University, School of MedicineErzurumTurkey
  3. 3.Department of UrologyAtatürk University, School of MedicineErzurumTurkey
  4. 4.Department of RadiologyBozok University, School of MedicineYozgatTurkey

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