Usefulness of T1 mapping on Gd-EOB-DTPA-enhanced MR imaging in assessment of non-alcoholic fatty liver disease
This study evaluates the value of Gd-EOB-DTPA-enhanced MRI for diagnosis and staging of non-alcoholic fatty liver disease (NAFLD) in an animal model by T1 relaxation time measurement.
Thirty-four rabbits were divided into the control group (n = 10) and NAFLD group, which was split into four groups (n = 6) with a high-fat diet for an interval of 3 weeks. A dual flip angle was performed before and at the hepatobiliary phase (HBP). T1 relaxation times of the liver parenchyma and the decrease rate (∆%) were calculated. Histological findings according to semi-quantitative scoring of steatosis, activity and fibrosis were the standard of reference.
HBP and ∆% T1 relaxation time measurement showed significant differences between normal and NAFLD groups, between non-alcoholic steatohepatitis (NASH) and NAFLD without NASH (p = 0.000–0.049), between fibrosis groups (p = 0.000–0.019), but no difference between F1 and F2 (p = 0.834). The areas under the receiver operating characteristic curves (AUCs) of T1 relaxation time for HBP and ∆% were 0.86–0.93 for the selection of NASH and activity score ≥2, and 0.86–0.95 for the selection of F ≥ 1, 2, 3. No significant difference was found for diagnostic performance between HBP and ∆% T1 relaxation time.
HBP T1 relaxation time measurement of Gd-EOB-DTPA-enhanced MRI was useful to evaluate NAFLD according to the SAF score. HBP T1 relaxation time measurement was as accurate as ∆% T1 relaxation time.
• Gd-EOB-DTPA-enhanced MRI could give useful information on NAFLD.
•HBP T1relaxation time measurement was useful for the evaluation of NAFLD.
• HBP T1relaxation time measurement was as accurate as ∆%.
KeywordsMagnetic resonance imaging T1 mapping Gd-EOB-DTPA NAFLD NASH
area under the ROC curve
least significant difference
magnetic resonance imaging
multidrug resistance protein
non-alcoholic fatty liver disease
organic anion transporting polypeptide
region of interest
receiver operating characteristic
steatosis (S), activity (A) and fibrosis (F)
volumetric interpolated breath-hold examination
The scientific guarantor of this publication is Mengsu Zeng. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This study received funding from the National Science Foundation for Young Scientists of China (Grant No. 81001025). One of the authors has significant statistical expertise. Institutional review board approval was obtained. Approval from the institutional animal care committee was obtained. No study subjects or cohorts have been previously reported.
Methodology: experimental study performed at one institution.
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