European Radiology

, Volume 24, Issue 4, pp 857–865 | Cite as

Efficacy of liver parenchymal enhancement and liver volume to standard liver volume ratio on Gd-EOB-DTPA-enhanced MRI for estimation of liver function

  • Tomohide Yoneyama
  • Yoshihiko Fukukura
  • Kiyohisa Kamimura
  • Koji Takumi
  • Aya Umanodan
  • Shinichi Ueno
  • Masayuki Nakajo
Magnetic Resonance



We aimed to develop and assess the efficacy of a liver function index that combines liver enhancement and liver volume to standard liver volume (LV/SLV) ratio on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI.


In all, 111 patients underwent a Gd-EOB-DTPA-enhanced MRI, including T1 mapping, before and 20 min after Gd-EOB-DTPA administration. We calculated the following Gd-EOB-DTPA-enhanced MRI-based liver function indices: relative enhancement of the liver, corrected enhancement of the liver-to-spleen ratio, LSC_N20, increase rate of the liver-to-muscle ratio, reduction rate of T1 relaxation time of the liver, ΔR1 of the liver and K Hep; the indices were multiplied by the LV/SLV ratio. We calculated the correlations between an indocyanine green (ICG) clearance and the Gd-EOB-DTPA-enhanced MRI-based liver function indices multiplied by the LV/SLV ratio, by using Pearson correlation analysis.


There were significant correlations between all Gd-EOB-DTPA-enhanced MRI-based liver function indices and ICG clearance (r = −0.354 to −0.574, P < 0.001). All Gd-EOB-DTPA-enhanced MRI-based liver function indices multiplied by the LV/SLV ratio (r = −0.394 to −0.700, P < 0.001) were more strongly correlated with the ICG clearance than those without multiplication by the LV/SLV ratio.


Gd-EOB-DTPA-enhanced MRI-based liver function indices that combine liver enhancement and the LV/SLV ratio may more reliably estimate liver function.

Key points

Gd-EOB-DTPA-enhanced MRI is useful for assessing liver function.

Liver enhancement on Gd-EOB-DTPA-enhanced MRI correlates with indocyanine green (ICG) clearance.

Liver volume to standard liver volume (LV/SLV) ratio correlates with ICG clearance.

Liver enhancement and LV/SLV ratio help to estimate liver function.


Gd-EOB-DTPA Magnetic resonance imaging Liver dysfunction Indocyanine green Liver 

Abbreviations and acronyms


body surface area


computed tomography


gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid


indocyanine green


liver volume


liver volume to standard liver volume


magnetic resonance imaging




volumetric interpolated breath-hold examination


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Copyright information

© European Society of Radiology 2013

Authors and Affiliations

  • Tomohide Yoneyama
    • 1
  • Yoshihiko Fukukura
    • 1
  • Kiyohisa Kamimura
    • 1
  • Koji Takumi
    • 1
  • Aya Umanodan
    • 1
  • Shinichi Ueno
    • 2
  • Masayuki Nakajo
    • 1
  1. 1.Department of RadiologyKagoshima University Graduate School of Medical and Dental SciencesKagoshima CityJapan
  2. 2.Department of Surgical Oncology and Digestive SurgeryKagoshima University Graduate School of Medical and Dental SciencesKagoshima CityJapan

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