Head and neck tumours: combined MRI assessment based on IVIM and TIC analyses for the differentiation of tumors of different histological types
We evaluated the combined use of intravoxel incoherent motion (IVIM) and time-signal intensity curve (TIC) analyses to diagnose head and neck tumours.
We compared perfusion-related parameters (PP) and molecular diffusion values (D) determined from IVIM theory and TIC profiles among 92 tumours with different histologies.
IVIM parameters (f and D values) and TIC profiles in combination were distinct among the different types of head and neck tumours, including squamous cell carcinomas (SCCs), lymphomas, malignant salivary gland tumours, Warthin’s tumours, pleomorphic adenomas and schwannomas. A multiparametric approach using both IVIM parameters and TIC profiles differentiated between benign and malignant tumours with 97 % accuracy and diagnosed different tumour types with 89 % accuracy.
Combined use of IVIM parameters and TIC profiles has high efficacy in diagnosing head and neck tumours.
• Head and neck tumours have wide MR perfusion/diffusion properties.
• Dynamic contrast-enhanced (DCE) MR imaging can characterise tumour perfusion (TIC analysis).
• Intravoxel incoherent motion (IVIM) imaging can provide diffusion and perfusion properties.
• However, IVIM or DCE imaging alone is insufficient for diagnosing head/neck tumours.
• Multiparametric approach using both IVIM and TIC profiles can facilitate the diagnosis.
KeywordsDiffusion-weighted MR imaging Intravoxel incoherent motion theory Contrast-enhanced MR imaging Head and neck tumours Differential diagnosis
intravoxel incoherent motion
time-signal intensity curve
squamous cell carcinoma
spectral attenuated with inversion recovery
echo planar imaging
Some patients of the present study cohort overlapped those of the previous study, which was published in the American Journal of Neuroradiology . In that paper, we evaluated IVIM parameters for diagnosing head and neck tumours, but not the combined assessment of TIC and IVIM parameters.
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