Ultrasound as a diagnostic tool in detecting active Crohn’s disease: a meta-analysis of prospective studies
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To evaluate the diagnostic accuracy of ultrasound in assessing active Crohn’s disease (CD) in adults.
We systematically searched PubMed, EMBASE, Web of Science and the Cochrane Library for prospective studies in which ultrasound was performed to evaluate active CD in adults from January 1993 to April 2013. Pooled sensitivity, specificity, positive and negative likelihood ratios (LR+ and LR−) and diagnostic odds ratios (DORs) in a per-patient-based analysis were estimated. Additionally, the area under the receiver-operating characteristic (ROC) curve was calculated to measure the diagnostic accuracy of ultrasound in patients with known or suspected CD.
Fifteen studies involving 1,558 patients were included in this meta-analysis. Overall, the pooled sensitivity (0.88) and LR- (0.14) were not heterogeneous, whereas the pooled specificity (0.97, I2 = 72.9 %) and LR + (15.10, I2 = 71.8 %) were. The DOR of ultrasound for assessing active CD was 121.70, with significant heterogeneity (I2 = 63.3 %). A symmetrical summary ROC curve was plotted showing that the area under the curve was 0.94, indicating good diagnostic accuracy. Meta-regression and subgroup analysis showed that the disease location may be a major cause of heterogeneity.
This meta-analysis suggests that ultrasound has high diagnostic accuracy in detecting active CD in adults, especially for small bowel CD.
• Ultrasound can detect active Crohn’s disease (CD).
• A meta-analysis of ultrasound for detecting active CD was carried out.
• This revealed that ultrasound has high diagnostic accuracy for detecting CD.
KeywordsUltrasound Crohn’s disease Meta-analysis
This study was supported in part by funding from the National Ministry of Health for the Digestive Disease (grant 201002020) and the National Natural Science Foundation of China (grants 81200263, 30972881 and 81170365).
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