European Radiology

, Volume 23, Issue 11, pp 2996–3004 | Cite as

Multi-sequence whole-brain intracranial vessel wall imaging at 7.0 tesla

  • Anja G. van der Kolk
  • Jeroen Hendrikse
  • Manon Brundel
  • Geert J. Biessels
  • Ewoud J. Smit
  • Fredy Visser
  • Peter R. Luijten
  • Jaco J. M. Zwanenburg
Neuro

Abstract

Objectives

Intracranial vessel wall magnetic resonance imaging (MRI) may improve the diagnosis of vessel wall abnormalities. Current methods are hampered by limited coverage and few contrast weightings. We present a multi-sequence protocol with whole-brain coverage for vessel wall imaging on 7.0-T MRI.

Methods

A modified magnetisation-preparation inversion recovery turbo-spin-echo (MPIR-TSE) sequence was used to obtain proton density (PD)-, T1-, and T2-weighting with 190-mm whole-brain coverage. Three observers independently scored the visibility of arterial vessel walls in five healthy volunteers, and compared the conspicuity and image contrast of all sequences. Clinical applicability was demonstrated in 17 patients with cerebrovascular disease.

Results

Conspicuity was good for all acquisitions, with best scores for the original limited-coverage sequence, followed by whole-brain coverage T2-, PD- and T1-weighted sequences, respectively. Mean vessel wall/background MR signal intensity ratios for all whole-brain sequences were similar, with higher scores for the limited-coverage MPIR-TSE sequence. Signal intensity ratios were highest in patients, for the whole-brain T1-weighted sequence.

Conclusions

The whole-brain multi-sequence vessel wall protocol can assess intracranial arterial vessel walls with full brain coverage, for different image contrast weightings. These sequences could eventually characterise intracranial vessel wall abnormalities similar to current techniques for assessing carotid artery plaques.

Key points

- Intracranial vessel wall imaging using MRI improves diagnosis of cerebrovascular diseases.

- Conventional 7-T MRI sequences cannot image the whole cerebral arterial tree.

- New whole-brain 7-T MRI sequences compare favourably with smaller-coverage sequences.

- These whole-brain sequences can demonstrate the entire cerebral arterial tree.

- These sequences should help in the diagnosis of vessel wall abnormalities.

Keywords

Intracranial arteriosclerosis Magnetic resonance imaging Cerebrovascular disorders Neuroimaging Cerebral arteries 

Abbreviations

HV

Healthy volunteers

MP

Magnetisation preparation mixing time

MPIR-TSE

Magnetisation preparation inversion recovery turbo-spin-echo

NSA

Number of signal averages

AP

Anterior–posterior

RL

Right-left

SAR

Specific absorption rate

SENSE

Sensitivity encoding

Notes

Acknowledgements

This research was performed within the framework of CTMM, the Center for Translational Molecular Medicine (www.ctmm.nl), project PARISk (grant 01C-202), and supported by the Dutch Heart Foundation. FredyVisser is an employee of Philips Healthcare, Best, The Netherlands.

References

  1. 1.
    Sacco RL, Kargman DE, Gu Q, Zamanillo MC (1995) Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction. The Northern Manhattan Stroke Study. Stroke 26:14–20PubMedCrossRefGoogle Scholar
  2. 2.
    Gorelick PB, Wong KS, Bae HJ, Pandey DK (2008) Large artery intracranial occlusive disease: a large worldwide burden but a relatively neglected frontier. Stroke 39:2396–2399PubMedCrossRefGoogle Scholar
  3. 3.
    Bash S, Villablanca JP, Jahan R et al (2005) Intracranial vascular stenosis and occlusive disease: evaluation with CT angiography, MR angiography, and digital subtraction angiography. AJNR Am J Neuroradiol 26:1012–1021PubMedGoogle Scholar
  4. 4.
    Miyazawa N, Akiyama I, Yamagata Z (2007) Analysis of incidence and risk factors for progression in patients with intracranial steno-occlusive lesions by serial magnetic resonance angiography. Clin Neurol Neurosurg 109:680–685PubMedCrossRefGoogle Scholar
  5. 5.
    Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ (1987) Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 316:1371–1375PubMedCrossRefGoogle Scholar
  6. 6.
    Stiel GM, Stiel LS, Schofer J, Donath K, Mathey DG (1989) Impact of compensatory enlargement of atherosclerotic coronary arteries on angiographic assessment of coronary artery disease. Circulation 80:1603–1609PubMedCrossRefGoogle Scholar
  7. 7.
    Kiechl S, Willeit J (1999) The natural course of atherosclerosis. Part II: vascular remodeling. Bruneck Study Group. Arterioscler Thromb Vasc Biol 19:1491–1498PubMedCrossRefGoogle Scholar
  8. 8.
    Niizuma K, Shimizu H, Takada S, Tominaga T (2008) Middle cerebral artery plaque imaging using 3-Tesla high-resolution MRI. J Clin Neurosci 15:1137–1141PubMedCrossRefGoogle Scholar
  9. 9.
    Li ML, Xu WH, Song L et al (2009) Atherosclerosis of middle cerebral artery: evaluation with high-resolution MR imaging at 3T. Atherosclerosis 204:447–452PubMedCrossRefGoogle Scholar
  10. 10.
    Swartz RH, Bhuta SS, Farb RI et al (2009) Intracranial arterial wall imaging using high-resolution 3-tesla contrast-enhanced MRI. Neurology 72:627–634PubMedCrossRefGoogle Scholar
  11. 11.
    Ryu CW, Jahng GH, Kim EJ, Choi WS, Yang DM (2009) High resolution wall and lumen MRI of the middle cerebral arteries at 3 tesla. Cerebrovasc Dis 27:433–442PubMedCrossRefGoogle Scholar
  12. 12.
    Xu WH, Li ML, Gao S et al (2010) In vivo high-resolution MR imaging of symptomatic and asymptomatic middle cerebral artery atherosclerotic stenosis. Atherosclerosis 212:507–511PubMedCrossRefGoogle Scholar
  13. 13.
    Ma N, Jiang WJ, Lou X et al (2010) Arterial remodeling of advanced basilar atherosclerosis: a 3-tesla MRI study. Neurology 75:253–258PubMedCrossRefGoogle Scholar
  14. 14.
    van der Kolk AG, Zwanenburg JJ, Brundel M et al (2011) Intracranial vessel wall imaging at 7.0-T MRI. Stroke 42:2478–2484PubMedCrossRefGoogle Scholar
  15. 15.
    Aoki S, Shirouzu I, Sasaki Y et al (1995) Enhancement of the intracranial arterial wall at MR imaging: relationship to cerebral atherosclerosis. Radiology 194:477–481PubMedGoogle Scholar
  16. 16.
    Turan TN, Bonilha L, Morgan PS, Adams RJ, Chimowitz MI (2011) Intraplaque hemorrhage in symptomatic intracranial atherosclerotic disease. J Neuroimaging 21:e159–e161PubMedCrossRefGoogle Scholar
  17. 17.
    Shi M, Wang S, Zhou H, Cheng Y, Feng J, Wu J (2012) Wingspan stenting of symptomatic middle cerebral artery stenosis and perioperative evaluation using high-resolution 3 Tesla MRI. J Clin Neurosci 19:912–914PubMedCrossRefGoogle Scholar
  18. 18.
    Visser F, Zwanenburg JJ, Hoogduin JM, Luijten PR (2010) High-resolution magnetization-prepared 3D-FLAIR imaging at 7.0 Tesla. Magn Reson Med 64:194–202PubMedCrossRefGoogle Scholar
  19. 19.
    Busse RF, Hariharan H, Vu A, Brittain JH (2006) Fast spin echo sequences with very long echo trains: design of variable refocusing flip angle schedules and generation of clinical T2 contrast. Magn Reson Med 55:1030–1037PubMedCrossRefGoogle Scholar
  20. 20.
    Smit EJ, Vonken EJ, van der Schaaf IC et al (2012) Timing-invariant reconstruction for deriving high-quality CT angiographic data from cerebral CT perfusion data. Radiology 263:216–225PubMedCrossRefGoogle Scholar
  21. 21.
    Vergouwen MD, Silver FL, Mandell DM, Mikulis DJ, Swartz RH (2011) Eccentric narrowing and enhancement of symptomatic middle cerebral artery stenoses in patients with recent ischemic stroke. Arch Neurol 68:338–342PubMedCrossRefGoogle Scholar
  22. 22.
    Lou X, Ma N, Ma L, Jiang WJ (2013) Contrast-enhanced 3T high-resolution mr imaging in symptomatic atherosclerotic basilar artery stenosis. AJNR Am J Neuroradiol 34:513–517PubMedCrossRefGoogle Scholar
  23. 23.
    Skarpathiotakis M, Mandell DM, Swartz RH, Tomlinson G, Mikulis DJ (2013) Intracranial atherosclerotic plaque enhancement in patients with ischemic stroke. AJNR Am J Neuroradiol 34:299–304PubMedCrossRefGoogle Scholar
  24. 24.
    Qiao Y, Steinman DA, Qin Q et al (2011) Intracranial arterial wall imaging using three-dimensional high isotropic resolution black blood MRI at 3.0 Tesla. J Magn Reson Imaging 34:22–30PubMedCrossRefGoogle Scholar
  25. 25.
    Scolding NJ (2009) Central nervous system vasculitis. Semin Immunopathol 31:527–536PubMedCrossRefGoogle Scholar
  26. 26.
    Pantoni L (2010) Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 9:689–701PubMedCrossRefGoogle Scholar
  27. 27.
    Bousser MG, Biousse V (2004) Small vessel vasculopathies affecting the central nervous system. J Neuroophthalmol 24:56–61PubMedCrossRefGoogle Scholar
  28. 28.
    Kim JM, Jung KH, Sohn CH, Moon J, Han MH, Roh JK (2012) Middle cerebral artery plaque and prediction of the infarction pattern. Arch Neurol 20:1–6Google Scholar

Copyright information

© European Society of Radiology 2013

Authors and Affiliations

  • Anja G. van der Kolk
    • 1
  • Jeroen Hendrikse
    • 1
  • Manon Brundel
    • 2
  • Geert J. Biessels
    • 2
  • Ewoud J. Smit
    • 1
  • Fredy Visser
    • 1
    • 4
  • Peter R. Luijten
    • 1
  • Jaco J. M. Zwanenburg
    • 1
    • 3
  1. 1.Department of RadiologyUniversity Medical Center UtrechtUtrechtThe Netherlands
  2. 2.Department of NeurologyUniversity Medical Center UtrechtUtrechtThe Netherlands
  3. 3.Image Sciences InstituteUniversity Medical Center UtrechtUtrechtThe Netherlands
  4. 4.Philips HealthcareBestThe Netherlands

Personalised recommendations