Capability of differentiating smokers with normal pulmonary function from COPD patients: a comparison of CT pulmonary volume analysis and MR perfusion imaging
- 571 Downloads
To compare CT volume analysis with MR perfusion imaging in differentiating smokers with normal pulmonary function (controls) from COPD patients.
Sixty-two COPD patients and 17 controls were included. The total lung volume (TLV), total emphysema volume (TEV) and emphysema index (EI) were quantified by CT. MR perfusion evaluated positive enhancement integral (PEI), maximum slope of increase (MSI), maximum slope of decrease (MSD), signal enhancement ratio (SER) and signal intensity ratio (RSI) of perfusion defects to normal lung.
There were 19 class I, 17 class II, 14 class III and 12 class IV COPD patients. No differences were observed in TLV, TEV and EI between control and class I COPD. The control was different from class II, III and IV COPD in TEV and EI. The control was different from each class of COPD in RSI, MSI, PEI and MSD. Differences were found in RSI between class I and III, I and IV, and II and IV COPD. Amongst controls, MR detected perfusion defects more frequently than CT detected emphysema.
Compared with CT, MR perfusion imaging shows higher potential to distinguish controls from mild COPD and appears more sensitive in identifying abnormalities amongst smokers with normal pulmonary function (controls).
• Detailed information is needed to diagnose chronic obstructive pulmonary disease.
• High-resolution CT provides detailed anatomical and quantitative information.
• Magnetic resonance imaging is demonstrating increasing potential in pulmonary function imaging.
• MR perfusion can distinguish mild COPD patients from controls.
• MRI appears more sensitive than CT in identifying early abnormalities amongst controls.
KeywordsChronic obstructive pulmonary disease Computed tomography Magnetic resonance perfusion imaging Smokers Early diagnosis
The authors would like to thank the Youth Fund of the National Natural Science Foundation of China (81000602), the Natural Science Foundation of Shanghai (10ZR1438900) and the National Natural Science Foundation of China (81171333, 30970800, 81071155 and 81271572) for the financial support.
- 1.Gold (2006) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Executive summary, updated http://www.goldcopd.org
- 3.Spaggiari E, Zompatori M, Verduri A et al (2005) Early smoking-induced lung lesions in asymptomatic subjects. Correlations between high resolution dynamic CT and pulmonary function testing. Radiol Med (Torino) 109:27–39Google Scholar
- 10.Kim SS, Seo JB, Kim N et al (2012) Improved correlation between CT emphysema quantification and pulmonary function test by density correction of volumetric CT data based on air and aortic density. Eur J Radiol. doi: 10.1016/j.ejrad.2012.02.021
- 19.Ogasawara N, Suga K, Zaki M et al (2004) Assessment of lung perfusion impairment in patients with pulmonary artery-occlusive and chronic obstructive pulmonary diseases with noncontrast electrocardiogram-gated fast-spin-echo perfusion MR imaging. J Magn Reson Imaging 20:601–611PubMedCrossRefGoogle Scholar
- 22.Ohno Y, Hatabu H, Murase K et al (2004) Quantitative assessment of regional pulmonary perfusion in the entire lung using three dimensional ultra fast dynamic contrast-enhanced magnetic resonance imaging: preliminary experience in 40 subjects. J Magn Reson Imaging 20:353–365PubMedCrossRefGoogle Scholar