European Radiology

, Volume 23, Issue 5, pp 1367–1374

T2* mapping and delayed gadolinium-enhanced magnetic resonance imaging in cartilage (dGEMRIC) of glenohumeral cartilage in asymptomatic volunteers at 3 T

  • Bernd Bittersohl
  • Falk R. Miese
  • Christin Dekkers
  • Hüseyin Senyurt
  • Jörn Kircher
  • Hans-Jörg Wittsack
  • Gerald Antoch
  • Rüdiger Krauspe
  • Christoph Zilkens
Magnetic Resonance

Abstract

Objectives

To establish baseline T2* and T1Gd values of glenohumeral cartilage at 3 T.

Methods

Forty asymptomatic volunteers (mean age: 24.8 ± 2.2 years) without shoulder abnormalities were included. The MRI protocol comprised a double-echo steady-state (DESS) sequence for morphological cartilage evaluation, a gradient-echo multiecho sequence for T2* assessment, and a gradient-echo dual-flip-angle sequence for T1Gd mapping. Statistical assessment involved a one-way analysis of variance (ANOVA) to identify the differences between various regions of the glenohumeral joint and intraclass correlation (ICC) analysis comparing repetitive T2* and T1Gd measures to assess intra- and interobserver reliability.

Results

Both techniques revealed significant differences between superior and inferior glenohumeral cartilage demonstrating higher T2* (26.2 ms vs. 23.2 ms, P value < 0.001) and T1Gd (750.1 ms vs. 720.2 ms, P value = 0.014) values in the superior regions. No trend was observed in the anterior-posterior measurement (P value range: 0.279–1.000). High intra- and interobserver agreement (ICC value range: 0.895–0.983) was noted for both T2* and T1Gd mapping.

Conclusions

T2* and T1Gd mapping are reliable in the assessment of glenohumeral cartilage. The values from this study can be used for comparison to identify cartilage degeneration in patients suffering from shoulder joint abnormalities.

Key Points

T2* mapping and dGEMRIC are sensitive to collagen degeneration and proteoglycan depletion.

This study aimed to establish baseline T2*/dGEMRIC values of glenohumeral cartilage.

Both techniques revealed significant differences between superior and inferior glenohumeral cartilage.

High intra-/interreader agreement was noted for both T2* mapping and dGEMRIC.

These baseline normal values should be useful when identifying potential degeneration.

Keywords

MRI T2* mapping dGEMRIC Shoulder Normative data 

Abbreviations and acronyms

OA

Osteoarthritis

GAG

Glycosaminoglycan

dGEMRIC

Delayed gadolinium-enhanced MRI of cartilage

GRE

Gradient echo

DESS

Double-echo steady state

MEDIC

Multiecho data image combination

FA

Flip angle

VIBE

Volumetric interpolated breathhold examination

ROI

Region of interest

ANOVA

Analysis of variance

ICC

Intraclass correlation

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Copyright information

© European Society of Radiology 2012

Authors and Affiliations

  • Bernd Bittersohl
    • 1
    • 4
  • Falk R. Miese
    • 2
  • Christin Dekkers
    • 1
  • Hüseyin Senyurt
    • 1
  • Jörn Kircher
    • 3
  • Hans-Jörg Wittsack
    • 2
  • Gerald Antoch
    • 2
  • Rüdiger Krauspe
    • 1
  • Christoph Zilkens
    • 1
  1. 1.Medical Faculty, Department of OrthopedicsUniversity DüsseldorfDüsseldorfGermany
  2. 2.Medical Faculty, Department of Diagnostic and Interventional RadiologyUniversity DüsseldorfDüsseldorfGermany
  3. 3.Department of Orthopedic SurgeryOrthoparc HospitalCologneGermany
  4. 4.Department of Orthopedics, Medical School, DüsseldorfHeinrich-Heine UniversityDüsseldorfGermany

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