European Radiology

, Volume 23, Issue 1, pp 190–197

Early diffuse recurrence of hepatocellular carcinoma after percutaneous radiofrequency ablation: analysis of risk factors

  • Hee Young Lee
  • Hyunchul Rhim
  • Min Woo Lee
  • Young-sun Kim
  • Dongil Choi
  • Min Jung Park
  • Young Kon Kim
  • Seong Hyun Kim
  • Hyo Keun Lim
Interventional

Abstract

Objective

To evaluate the risk factors affecting early diffuse recurrence within 1 year of percutaneous ultrasound-guided radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC).

Methods

Out of 146 patients who received transcatheter arterial chemoembolisation (TACE) for treatment of recurrent HCC after percutaneous ultrasound-guided RFA, we selected 23 patients with early diffuse recurrence. Early diffuse recurrence was defined as three or more new recurrent HCCs within 1 year of initial RFA. As a control group, we selected 23 patients, matched exactly for age and sex, in which there was no local tumour progression or new recurrence after RFA. To analyse the risk factors, we examined patient factors and tumour factors.

Results

Recurrent tumours occurred from 30 to 365 days after RFA (median time, 203 days). Univariate analysis indicated that larger tumour size and poorly defined margin were significant risk factors (P < 0.05). Multivariate analysis indicated that poorly defined margin was a significant risk factor (P < 0.05).

Conclusion

Larger tumour size and poorly defined margin may be risk factors for early diffuse recurrence of HCC within 1 year of RFA. Tumours with such risk factors should be treated with a combination of TACE to minimise the potential for therapeutic failure.

Key Points

Ultrasound-guided radiofrequency ablation (RFA) is widely used for hepatocellular carcinoma (HCC).

Early diffuse recurrence after RFA is an important prognostic factor

The risk factors for recurrence are larger tumour size and poorly defined margins

Tumours with such risk factors should be treated with transarterial chemoembolisation.

Keywords

Hepatocellular carcinomas Radiofrequency catheter ablation Percutaneous catheter ablation Recurrence Risk factors 

Copyright information

© European Society of Radiology 2012

Authors and Affiliations

  • Hee Young Lee
    • 1
  • Hyunchul Rhim
    • 1
  • Min Woo Lee
    • 1
  • Young-sun Kim
    • 1
  • Dongil Choi
    • 1
  • Min Jung Park
    • 1
  • Young Kon Kim
    • 1
  • Seong Hyun Kim
    • 1
  • Hyo Keun Lim
    • 1
  1. 1.Department of Radiology and Center for Imaging ScienceSamsung Medical Center, Sungkyunwan University, School of MedicineSeoulKorea

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