Comparison of clinical semi-quantitative assessment of muscle fat infiltration with quantitative assessment using chemical shift-based water/fat separation in MR studies of the calf of post-menopausal women
The goal of this study was to compare the semi-quantitative Goutallier classification for fat infiltration with quantitative fat-fraction derived from a magnetic resonance imaging (MRI) chemical shift-based water/fat separation technique.
Sixty-two women (age 61 ± 6 years), 27 of whom had diabetes, underwent MRI of the calf using a T1-weighted fast spin-echo sequence and a six-echo spoiled gradient-echo sequence at 3 T. Water/fat images and fat fraction maps were reconstructed using the IDEAL algorithm with T2* correction and a multi-peak model for the fat spectrum. Two radiologists scored fat infiltration on the T1-weighted images using the Goutallier classification in six muscle compartments. Spearman correlations between the Goutallier grades and the fat fraction were calculated; in addition, intra-observer and inter-observer agreement were calculated.
A significant correlation between the clinical grading and the fat fraction values was found for all muscle compartments (P < 0.0001, R values ranging from 0.79 to 0.88). Goutallier grades 0–4 had a fat fraction ranging from 3.5 to 19%. Intra-observer and inter-observer agreement values of 0.83 and 0.81 were calculated for the semi-quantitative grading.
Semi-quantitative grading of intramuscular fat and quantitative fat fraction were significantly correlated and both techniques had excellent reproducibility. However, the clinical grading was found to overestimate muscle fat.
• Fat infiltration of muscle commonly occurs in many metabolic and neuromuscular diseases.
• Image-based semi-quantitative classifications for assessing fat infiltration are not well validated.
• Quantitative MRI techniques provide an accurate assessment of muscle fat.
KeywordsSkeletal muscle Magnetic resonance imaging Adipose tissue Metabolic syndrome Neuromuscular disease Sarcopenia
This study was supported by the National Institutes of Health grants R01-AG17762 and RC1-AR058405.
- 10.Gaeta M, Scribano E, Mileto A et al (2011) Muscle fat fraction in neuromuscular disorders: dual-echo dual-flip-angle spoiled gradient-recalled MR imaging technique for quantification—a feasibility study. Radiology. doi: 10.1148/radiol.10101108
- 11.Karampinos DC, Baum T, Nardo L et al (2011) Characterization of regional distribution of skeletal muscle adipose tissue in type 2 diabetes using chemical shift-based water/fat separation. J Magn Reson Imaging. doi: 10.1002/jmri.23512
- 23.Middleton MS, Hamilton G, Bydder M, Sirlin CB (2009) How much fat is under the water peak in liver fat MR spectroscopy? In: Proceedings of the 17th Annual Meeting of ISMRM, Honolulu, p 4331Google Scholar