European Radiology

, Volume 21, Issue 12, pp 2503–2510 | Cite as

Heart and liver T2* assessment for iron overload using different software programs

  • Juliano L. FernandesEmail author
  • Erika Fontana Sampaio
  • Monica Verissimo
  • Fabricio B. Pereira
  • Jose Alvaro da Silva
  • Gabriel S. de Figueiredo
  • Jose M. Kalaf
  • Otavio R. Coelho



To assess the level of agreement and interchangeability among different software programs for calculation of T2* values for iron overload.


T2* images were analysed in 60 patients with thalassaemia major using the truncation method in three software programs. Levels of agreement were assessed using Pearson correlation and Bland-Altman plots. Categorical classification for levels of iron concentration by each software program was also compared.


For the heart, all correlation coefficients were significant among the software programs (P < 0.001 for all coefficients). The mean differences and 95% limits of agreement were 0.2 (−4.73 to 5.0); 0.1 (−4.0 to 3.9); and −0.1 (−4.3 to 4.8). For the liver all correlations were also significant with P < 0.001. Bland-Altman plots showed differences of −0.02 (−0.7 to 0.6); 0.01 (−0.4 to 0.4); and −0.02 (−0.6 to 0.6). There were no significant differences in clinical classification among the software programs.


All tools used in this study provided very good agreement among heart and liver T2* values. The results indicate that interpretation of T2* data is interchangeable with any of the software programs tested.

Key Points

  • Magnetic resonance imaging in iron overload assessment has become an essential tool.

  • Post processing options to establish T2* values have not been compared.

  • No differences were found on T2* of the liver or heart using 3 different techniques.

  • Availability of these methods should allow more widespread interpretation of iron overload by MRI.


Magnetic resonance Iron overload Thalassemia Software Hemosiderosis 



This work was supported by a grant from the public funding agency Fundacao de Amparo a Pesquisa do Estado de Sao Paulo.


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Copyright information

© European Society of Radiology 2011

Authors and Affiliations

  • Juliano L. Fernandes
    • 1
    • 2
    • 4
    Email author
  • Erika Fontana Sampaio
    • 1
  • Monica Verissimo
    • 3
  • Fabricio B. Pereira
    • 3
  • Jose Alvaro da Silva
    • 2
  • Gabriel S. de Figueiredo
    • 2
  • Jose M. Kalaf
    • 2
  • Otavio R. Coelho
    • 1
  1. 1.University of Campinas, UnicampCampinasBrazil
  2. 2.Radiologia Clinica de CampinasCampinasBrazil
  3. 3.Centro Infantil BoldriniCampinasBrazil
  4. 4.Department of Internal MedicineCardiologyCampinasBrazil

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