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European Radiology

, 21:2427 | Cite as

Diffusion tensor imaging and tractography for assessment of renal allograft dysfunction—initial results

  • Katja Hueper
  • M. Gutberlet
  • T. Rodt
  • W. Gwinner
  • F. Lehner
  • F. Wacker
  • M. Galanski
  • D. Hartung
Urogenital

Abstract

Objectives

To evaluate MR diffusion tensor imaging (DTI) as non-invasive diagnostic tool for detection of acute and chronic allograft dysfunction and changes of organ microstructure.

Methods

15 kidney transplanted patients with allograft dysfunction and 14 healthy volunteers were examined using a fat-saturated echo-planar DTI-sequence at 1.5 T (6 diffusion directions, b = 0, 600 s/mm²). Mean apparent diffusion coefficient (ADC) and mean fractional anisotropy (FA) were calculated separately for the cortex and for the medulla and compared between healthy and transplanted kidneys. Furthermore, the correlation between diffusion parameters and estimated GFR was determined.

Results

The ADC in the cortex and in the medulla were lower in transplanted than in healthy kidneys (p < 0.01). Differences were more distinct for FA, especially in the renal medulla, with a significant reduction in allografts (p < 0.001). Furthermore, in transplanted patients a correlation between mean FA in the medulla and estimated GFR was observed (r = 0.72, p < 0.01). Tractography visualized changes in renal microstructure in patients with impaired allograft function.

Conclusions

Changes in allograft function and microstructure can be detected and quantified using DTI. However, to prove the value of DTI for standard clinical application especially correlation of imaging findings and biopsy results is necessary.

Keywords

Kidney transplantation Diffusion tensor imaging Anisotropy Diffusion magnetic resonance imaging Glomerular filtration rate 

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Copyright information

© European Society of Radiology 2011

Authors and Affiliations

  • Katja Hueper
    • 1
  • M. Gutberlet
    • 1
  • T. Rodt
    • 1
  • W. Gwinner
    • 2
  • F. Lehner
    • 3
  • F. Wacker
    • 1
  • M. Galanski
    • 1
  • D. Hartung
    • 1
  1. 1.Hannover Medical School—GermanyInstitute for Diagnostic and Interventional RadiologyHannoverGermany
  2. 2.Hannover Medical School—GermanyClinic for NephrologyHannoverGermany
  3. 3.Hannover Medical School—GermanyClinic for General, Abdominal and Transplant SurgeryHannoverGermany

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