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European Radiology

, Volume 21, Issue 7, pp 1439–1446 | Cite as

Feasibility of simultaneous PET/MR imaging in the head and upper neck area

  • Andreas BossEmail author
  • Lars Stegger
  • Sotirios Bisdas
  • Armin Kolb
  • Nina Schwenzer
  • Markus Pfister
  • Claus D. Claussen
  • Bernd J. Pichler
  • Christina Pfannenberg
Head and Neck

Abstract

Objective

The aim of this pilot study was to test and demonstrate the feasibility of simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) of the head and upper neck area using a new hybrid PET/MRI system.

Methods

Eight patients with malignant head and neck tumours were included in the pilot study. Directly after routine PET/CT imaging with a whole-body system using the glucose derivative 2-[18F]fluoro-2deoxy-D-glucose (FDG) as a radiotracer additional measurements were performed with a prototype PET/MRI system for simultaneous PET and MR imaging. Physiological radiotracer uptake within regular anatomical structures as well as tumour uptake were evaluated visually and semiquantitatively (metabolic ratios) in relation to cerebellar uptake on the PET/MRI and PET/CT systems.

Results

The MR datasets showed excellent image quality without any recognisable artefacts caused by the inserted PET system. PET images obtained with the PET/MRI system exhibited better detailed resolution and greater image contrast in comparison to those from the PET/CT system. An excellent agreement between metabolic ratios obtained with both PET systems was found: R = 0.99 for structures with physiological tracer uptake, R = 0.96 for tumours.

Conclusion

Simultaneous PET/MRI of the head and upper neck area is feasible with the new hybrid PET/MRI prototype.

Keywords

PET/MRI Hybrid imaging Head and neck tumours Oncology 

Notes

Acknowledgements

We would like to thank the staff of the cyclotron and radiochemistry facilities of Tübingen University and all contributing members of Siemens Healthcare for the continuous support. Furthermore, we acknowledge Heinz-Peter Schlemmer, Thomas Nägele, Roland Bares, Ulrike Ernemann, Martin Heuschmid, Matthias Hofmann, Matthias Reimold and Frédéric Mantlik for their contributions. Financial research support was provided through the “Deutsche Forschungsgemeinschaft” (grants PI771/5-1 and PI771/1-1, and SFB 656 Münster, project C6) as well as through the Swiss Werner Siemens-Foundation. Part of this work was supported by the Herzzentrum Münster e.V. (travel grant to L.S.).

References

  1. 1.
    Guntinas-Lichius O, Wendt T, Buentzel J, Esser D, Lochner P, Mueller A, Schultze-Mosgau S, Altendorf-Hofmann A (2010) Head and neck cancer in Germany: a site-specific analysis of survival of the Thuringian cancer registration database. J Cancer Res Clin Oncol 136:55–63PubMedCrossRefGoogle Scholar
  2. 2.
    Gardner M, Halimi P, Valinta D, Plantet MM, Alberini JL, Wartski M, Banal A, Hans S, Floiras JL, Housset M, Labib A (2009) Use of single MRI and 18 F-FDG PET-CT scans in both diagnosis and radiotherapy treatment planning in patients with head and neck cancer: advantage on target volume and critical organ delineation. Head Neck 31:461–467PubMedCrossRefGoogle Scholar
  3. 3.
    Goerres GW, Mosna-Firlejczyk K, Steurer J, von Schulthess GK, Bachmann LM (2003) Assessment of clinical utility of 18F-FDG PET in patients with head and neck cancer: a probability analysis. Eur J Nucl Med Mol Imaging 30:562–571PubMedCrossRefGoogle Scholar
  4. 4.
    Bruschini P, Giorgetti A, Bruschini L, Nacci A, Volterrani D, Cosottini M, Ursino F, Mariani G, Fattori B (2003) Positron emission tomography (PET) in the staging of the head neck cancer: comparison between PET and CT. Acta Otorhinolaryngol Ital 23:446–453PubMedGoogle Scholar
  5. 5.
    Comoretto M, Balestreri L, Borsatti E, Cimitan M, Franchin G, Lise M (2008) Detection and restaging of residual and/or recurrent nasopharyngeal carcinoma after chemotherapy and radiation therapy: comparison of MR imaging and FDG PET/CT. Radiology 249:203–11PubMedCrossRefGoogle Scholar
  6. 6.
    Anzai Y, Carroll WR, Quint DJ, Bradford CR, Minoshima S, Wolf GT, Wahl RL (1996) Recurrence of head and neck cancer after surgery or irradiation: prospective comparison of 2-deoxy-2- [F-18] fluoro-D-glucose PET and MR imaging diagnoses. Radiology 200:135–141PubMedGoogle Scholar
  7. 7.
    Judenhofer MS, Wehrl HF, Newport DF, Catana C, Siegel SB, Becker M, Thielscher A, Kneilling M, Lichy MP, Eichner M, Klingel K, Reischl G, Widmaier S, Röcken M, Nutt RE, Machulla HJ, Uludag K, Cherry SR, Claussen CD, Pichler BJ (2008) Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nat Med 14:459–465PubMedCrossRefGoogle Scholar
  8. 8.
    Schlemmer HP, Pichler BJ, Schmand M, Burbar Z, Michel C, Ladebeck R, Jattke K, Townsend D, Nahmias C, Jacob PK, Heiss WD, Claussen CD (2008) Simultaneous MR/PET imaging of the human brain: feasibility study. Radiology 248:1028–1035PubMedCrossRefGoogle Scholar
  9. 9.
    Brambilla M, Secco C, Dominietto M, Matheoud R, Sacchetti G, Inglese E (2005) Performance characteristics obtained for a new 3-dimensional lutetium oxyorthosilicate-based whole-body PET/CT scanner with the National Electrical Manufacturers Association NU 2-2001 standard. J Nucl Med 46:2083–2091PubMedGoogle Scholar
  10. 10.
    Comtat C, Bataille F, Michel C, Jones JP, Sibomana M, Janeiro L, Trebossen R (2004) OSEM-3D reconstruction strategies for the ECAT HRRT. In: Conference Record of the 2004 Institute of Electrical and Electronics Engineers (IEEE) Nuclear Science Symposium and Medical Imaging Conference. Piscataway, NJ: IEEE 3492–3496Google Scholar
  11. 11.
    Hofmann M, Steinke F, Scheel V, Charpiat G, Farquhar J, Aschoff P, Brady M, Schölkopf B, Pichler BJ (2008) MRI-based attenuation correction for PET/MRI: a novel approach combining pattern recognition and atlas registration. J Nucl Med 49:1875–1883PubMedCrossRefGoogle Scholar
  12. 12.
    Jabour BA, Choi Y, Hoh CK, Rege SD, Soong JC, Lufkin RB, Hanafee WN, Maddahi J, Chaiken L, Bailet J et al (1993) Extracranial head and neck: PET imaging with 2-[F-18]fluoro-2-deoxy-D-glucose and MR imaging correlation. Radiology 186:27–35PubMedGoogle Scholar
  13. 13.
    Rege SD, Chaiken L, Hoh CK, Choi Y, Lufkin R, Anzai Y, Juillard G, Maddahi J, Phelps ME, Hawkins RA (1993) Change induced by radiation therapy in FDG uptake in normal and malignant structures of the head and neck: quantitation with PET. Radiology 189:807–812PubMedGoogle Scholar

Copyright information

© European Society of Radiology 2011

Authors and Affiliations

  • Andreas Boss
    • 1
    • 2
    • 6
    Email author
  • Lars Stegger
    • 3
    • 1
  • Sotirios Bisdas
    • 4
  • Armin Kolb
    • 2
  • Nina Schwenzer
    • 1
  • Markus Pfister
    • 5
  • Claus D. Claussen
    • 1
  • Bernd J. Pichler
    • 2
  • Christina Pfannenberg
    • 1
  1. 1.Department of Diagnostic and Interventional RadiologyEberhard-Karls UniversityTübingenGermany
  2. 2.Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, Department for Preclinical Imaging and RadiopharmacyTübingenGermany
  3. 3.Department of Nuclear Medicine and Institute for Molecular ImagingUniversity of MünsterMünsterGermany
  4. 4.Department of Diagnostic and Interventional NeuroradiologyEberhard-Karls UniversityTübingenGermany
  5. 5.Department of Otolaryngology, Head and Neck SurgeryEberhard-Karls UniversityTübingenGermany
  6. 6.Department of Diagnostic and Interventional RadiologyUniversity Hospital of ZurichZurichSwitzerland

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