European Radiology

, Volume 21, Issue 6, pp 1136–1143 | Cite as

Biochemical (T2, T2* and magnetisation transfer ratio) MRI of knee cartilage: feasibility at ultra-high field (7T) compared with high field (3T) strength

  • Goetz H. WelschEmail author
  • Sebastian Apprich
  • Stefan Zbyn
  • Tallal C. Mamisch
  • Vladimir Mlynarik
  • Klaus Scheffler
  • Oliver Bieri
  • Siegfried Trattnig



This study compares the performance and the reproducibility of quantitative T2, T2* and the magnetisation transfer ratio (MTR) of articular cartilage at 7T and 3T.


Axial MRI of the patella was performed in 17 knees of healthy volunteers (25.8 ± 5.7 years) at 3T and 7T using a comparable surface coil and whole-body MR systems from the same vendor, side-by-side. Thirteen knee joints were assessed once, and four knee joints were measured three times to assess reproducibility. T2 relaxation was prepared by a multi-echo, spin-echo sequence and T2* relaxation by a multi-echo, gradient-echo sequence. MTR was based on a magnetisation transfer-sensitized, steady-state free precession approach. Statistical analysis-of-variance and coefficient-of-variation (CV) were prepared.


For T2 and T2*, global values were significantly lower at 7T compared with 3T; the zonal evaluation revealed significantly less pronounced stratification at 7T (p < 0.05). MTR provided higher values at 7T (p < 0.05). CV, indicating reproducibility, showed slightly lower values at 7T, but only for T2 and T2*.


Although lower T2 and T2* relaxation times were expected at 7T, the differences in stratification between the field strengths were reported for the first time. The assessment of MT is feasible at 7T, but requires further investigation.


T2 T2* Magnetisation transfer Cartilage 3 Tesla 7 Tesla 



Funding for this study was provided by the project “Vienna Advanced Clinical Imaging Center” (VIACLIC), within the “Vienna Spots Of Excellence” program; a collaboration of the Medical University of Vienna and Siemens Austria.


  1. 1.
    Felson DT (2004) Risk factors for osteoarthritis: understanding joint vulnerability. Clin Orthop Relat Res:S16-21Google Scholar
  2. 2.
    Potter HG, Black BR, le Chong R (2009) New techniques in articular cartilage imaging. Clin Sports Med 28:77–94PubMedCrossRefGoogle Scholar
  3. 3.
    Welsch GH, Mamisch TC, Hughes T, Domayer S, Marlovits S, Trattnig S (2008) Advanced morphological and biochemical magnetic resonance imaging of cartilage repair procedures in the knee joint at 3 Tesla. Semin Musculoskelet Radiol 12:196–211PubMedCrossRefGoogle Scholar
  4. 4.
    Regatte RR, Schweitzer ME (2008) Novel contrast mechanisms at 3 Tesla and 7 Tesla. Semin Musculoskelet Radiol 12:266–280PubMedCrossRefGoogle Scholar
  5. 5.
    Burstein D, Velyvis J, Scott KT et al (2001) Protocol issues for delayed Gd(DTPA)(2-)-enhanced MRI: (dGEMRIC) for clinical evaluation of articular cartilage. Magnetic Resonance in Medicine 45:36–41PubMedCrossRefGoogle Scholar
  6. 6.
    Mosher TJ, Dardzinski BJ (2004) Cartilage MRI T2 relaxation time mapping: overview and applications. Semin Musculoskelet Radiol 8:355–368PubMedCrossRefGoogle Scholar
  7. 7.
    Potter K, Butler JJ, Horton WE, Spencer RG (2000) Response of engineered cartilage tissue to biochemical agents as studied by proton magnetic resonance microscopy. Arthritis Rheum 43:1580–1590PubMedCrossRefGoogle Scholar
  8. 8.
    Pakin SK, Cavalcanti C, La Rocca R, Schweitzer ME, Regatte RR (2006) Ultra-high-field MRI of knee joint at 7.0T: preliminary experience. Acad Radiol 13:1135–1142PubMedCrossRefGoogle Scholar
  9. 9.
    Welsch GH, Mamisch TC, Hughes T et al (2008) In vivo biochemical 7.0 Tesla magnetic resonance: preliminary results of dGEMRIC, zonal T2, and T2* mapping of articular cartilage. Invest Radiol 43:619–626PubMedCrossRefGoogle Scholar
  10. 10.
    Bieri O, Scheffler K (2007) Optimized balanced steady-state free precession magnetization transfer imaging. Magn Reson Med 58:511–518PubMedCrossRefGoogle Scholar
  11. 11.
    Welsch GH, Trattnig S, Scheffler K et al (2008) Magnetization transfer contrast and T2 mapping in the evaluation of cartilage repair tissue with 3T MRI. J Magn Reson Imaging 28:979–986PubMedCrossRefGoogle Scholar
  12. 12.
    Liess C, Lusse S, Karger N, Heller M, Gluer CC (2002) Detection of changes in cartilage water content using MRI T2-mapping in vivo. Osteoarthritis Cartilage 10:907–913PubMedCrossRefGoogle Scholar
  13. 13.
    Goodwin DW, Wadghiri YZ, Dunn JF (1998) Micro-imaging of articular cartilage: T2, proton density, and the magic angle effect. Acad Radiol 5:790–798PubMedCrossRefGoogle Scholar
  14. 14.
    Goodwin DW, Zhu H, Dunn JF (2000) In vitro MR imaging of hyaline cartilage: correlation with scanning electron microscopy. AJR Am J Roentgenol 174:405–409PubMedGoogle Scholar
  15. 15.
    Rubenstein JD, Kim JK, Morova-Protzner I, Stanchev PL, Henkelman RM (1993) Effects of collagen orientation on MR imaging characteristics of bovine articular cartilage. Radiology 188:219–226PubMedGoogle Scholar
  16. 16.
    Mosher TJ, Collins CM, Smith HE et al (2004) Effect of gender on in vivo cartilage magnetic resonance imaging T2 mapping. J Magn Reson Imaging 19:323–328PubMedCrossRefGoogle Scholar
  17. 17.
    Smith HE, Mosher TJ, Dardzinski BJ et al (2001) Spatial variation in cartilage T2 of the knee. J Magn Reson Imaging 14:50–55PubMedCrossRefGoogle Scholar
  18. 18.
    Welsch GH, Mamisch TC, Domayer SE et al (2008) Cartilage T2 assessment at 3-T MR imaging: in vivo differentiation of normal hyaline cartilage from reparative tissue after two cartilage repair procedures–initial experience. Radiology 247:154–161PubMedCrossRefGoogle Scholar
  19. 19.
    Welsch GH, Mamisch TC, Marlovits S et al (2009) Quantitative T2 mapping during follow-up after matrix-associated autologous chondrocyte transplantation (MACT): Full-thickness and zonal evaluation to visualize the maturation of cartilage repair tissue. J Orthop Res 27:957–963PubMedCrossRefGoogle Scholar
  20. 20.
    Mlynarik V, Degrassi A, Toffanin R, Vittur F, Cova M, Pozzi-Mucelli RS (1996) Investigation of laminar appearance of articular cartilage by means of magnetic resonance microscopy. Magn Reson Imaging 14:435–442PubMedCrossRefGoogle Scholar
  21. 21.
    Mlynarik V, Szomolanyi P, Toffanin R, Vittur F, Trattnig S (2004) Transverse relaxation mechanisms in articular cartilage. J Magn Reson 169:300–307PubMedCrossRefGoogle Scholar
  22. 22.
    Bittersohl B, Hosalkar HS, Hughes T et al (2009) Feasibility of T2* mapping for the evaluation of hip joint cartilage at 1.5T using a three-dimensional (3D), gradient-echo (GRE) sequence: a prospective study. Magn Reson Med 62:896–901PubMedCrossRefGoogle Scholar
  23. 23.
    Welsch GH, Trattnig S, Hughes T et al (2009) T2 and T2* mapping in patients after matrix-associated autologous chondrocyte transplantation: initial results on clinical use with 3.0-Tesla MRI. Eur Radiol 19:1253–1262PubMedCrossRefGoogle Scholar
  24. 24.
    Maroudas A, Bayliss MT, Venn MF (1980) Further studies on the composition of human femoral head cartilage. Ann Rheum Dis 39:514–523PubMedCrossRefGoogle Scholar
  25. 25.
    Quaia E, Toffanin R, Guglielmi G et al (2008) Fast T2 mapping of the patellar articular cartilage with gradient and spin-echo magnetic resonance imaging at 1.5T: validation and initial clinical experience in patients with osteoarthritis. Skeletal Radiol 37:511–517PubMedCrossRefGoogle Scholar
  26. 26.
    Hannila I, Raina SS, Tervonen O, Ojala R, Nieminen MT (2009) Topographical variation of T2 relaxation time in the young adult knee cartilage at 1.5T. Osteoarthritis Cartilage 17:1570–1575PubMedCrossRefGoogle Scholar
  27. 27.
    Mosher TJ, Liu Y, Torok CM (2010) Functional cartilage MRI T2 mapping: evaluating the effect of age and training on knee cartilage response to running. Osteoarthritis Cartilage 18:358–364PubMedCrossRefGoogle Scholar
  28. 28.
    Welsch GH, Mamisch TC, Quirbach S, Zak L, Marlovits S, Trattnig S (2009) Evaluation and comparison of cartilage repair tissue of the patella and medial femoral condyle by using morphological MRI and biochemical zonal T2 mapping. Eur Radiol 19:1253–1262PubMedCrossRefGoogle Scholar
  29. 29.
    Mamisch TC, Trattnig S, Quirbach S, Marlovits S, White LM, Welsch GH (2010) Quantitative T2 Mapping of Knee Cartilage: Differentiation of Healthy Control Cartilage and Cartilage Repair Tissue in the Knee with Unloading–Initial Results. Radiology 254:812–826CrossRefGoogle Scholar
  30. 30.
    Stehling C, Liebl H, Krug R et al (2010) Patellar cartilage: T2 values and morphologic abnormalities at 3.0-T MR imaging in relation to physical activity in asymptomatic subjects from the osteoarthritis initiative. Radiology 254:509–520PubMedCrossRefGoogle Scholar

Copyright information

© European Society of Radiology 2010

Authors and Affiliations

  • Goetz H. Welsch
    • 1
    • 2
    Email author
  • Sebastian Apprich
    • 1
  • Stefan Zbyn
    • 1
  • Tallal C. Mamisch
    • 1
    • 3
  • Vladimir Mlynarik
    • 4
  • Klaus Scheffler
    • 5
  • Oliver Bieri
    • 5
  • Siegfried Trattnig
    • 1
  1. 1.MR Center, Department of RadiologyMedical University of ViennaViennaAustria
  2. 2.Department of Trauma SurgeryUniversity of ErlangenErlangenGermany
  3. 3.Department of Orthopedic SurgeryUniversity of BerneBerneSwitzerland
  4. 4.Laboratory of functional and metabolic imagingEcole Polytechnique Federale de LausanneLausanneSwitzerland
  5. 5.Division of Radiological Physics, Institute of RadiologyUniversity Hospital BaselBaselSwitzerland

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