European Radiology

, Volume 21, Issue 1, pp 11–17

Detection of non-palpable breast cancer in asymptomatic women by using unenhanced diffusion-weighted and T2-weighted MR imaging: comparison with mammography and dynamic contrast-enhanced MR imaging

  • Hidetake Yabuuchi
  • Yoshio Matsuo
  • Shunya Sunami
  • Takeshi Kamitani
  • Satoshi Kawanami
  • Taro Setoguchi
  • Shuji Sakai
  • Masamitsu Hatakenaka
  • Makoto Kubo
  • Eriko Tokunaga
  • Hidetaka Yamamoto
  • Hiroshi Honda
Breast

DOI: 10.1007/s00330-010-1890-8

Cite this article as:
Yabuuchi, H., Matsuo, Y., Sunami, S. et al. Eur Radiol (2011) 21: 11. doi:10.1007/s00330-010-1890-8

Abstract

Objective

To compare the detectability of non-palpable breast cancer in asymptomatic women by using mammography (MMG), dynamic contrast-enhanced MR imaging (DCE-MRI) and unenhanced MR imaging with combined diffusion-weighted and T2-weighted images (DWI + T2WI).

Methods

Forty-two lesions in 42 patients with non-palpable breast cancer in asymptomatic women were enrolled. For the reading test, we prepared a control including 13 normal and 8 benign cases. Each imaging set included biplane MMG, DCE-MRI and DWI + T2WI. Five readers were asked to rate the images on a scale of 0 to 100 for the likelihood of the presence of cancer and the BI-RADS category. Confidence level results were used to construct receiver operating characteristic analysis. Sensitivity and specificity were calculated for each technique.

Results

DWI + T2WI showed higher observer performances (area under the curve, AUC, 0.73) and sensitivity (50%) for the detection of non-palpable breast cancer than MMG alone (AUC 0.64; sensitivity 40%) but lower than those of DCE-MRI (AUC 0.93; sensitivity 86%). A combination of MMG and DWI + T2WI exhibited higher sensitivity (69%) compared with that of MMG alone (40%).

Conclusion

DWI + T2WI could be useful in screening breast cancer for patients who cannot receive contrast medium and could be used as a new screening technique for breast cancer.

Keyword

Breast Magnetic resonance imaging Diffusion-weighted MR image Non-palpable cancer Screening 

Copyright information

© European Society of Radiology 2010

Authors and Affiliations

  • Hidetake Yabuuchi
    • 1
  • Yoshio Matsuo
    • 1
  • Shunya Sunami
    • 1
  • Takeshi Kamitani
    • 1
  • Satoshi Kawanami
    • 1
  • Taro Setoguchi
    • 1
  • Shuji Sakai
    • 2
  • Masamitsu Hatakenaka
    • 1
  • Makoto Kubo
    • 3
  • Eriko Tokunaga
    • 4
  • Hidetaka Yamamoto
    • 5
  • Hiroshi Honda
    • 1
  1. 1.Department of Clinical Radiology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  2. 2.Department of Health Sciences, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  3. 3.Department of Clinical Oncology and Surgery, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  4. 4.Department of Surgery and Science, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  5. 5.Department of Anatomic Pathology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

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