European Radiology

, Volume 20, Issue 12, pp 2844–2852 | Cite as

Cardiac chamber quantification using magnetic resonance imaging at 7 Tesla—a pilot study

  • Florian von Knobelsdorff-BrenkenhoffEmail author
  • Tobias Frauenrath
  • Marcel Prothmann
  • Matthias A. Dieringer
  • Fabian Hezel
  • Wolfgang Renz
  • Kerstin Kretschel
  • Thoralf Niendorf
  • Jeanette Schulz-Menger



Interest in cardiovascular magnetic resonance (CMR) at 7 T is motivated by the expected increase in spatial and temporal resolution, but the method is technically challenging. We examined the feasibility of cardiac chamber quantification at 7 T.


A stack of short axes covering the left ventricle was obtained in nine healthy male volunteers. At 1.5 T, steady-state free precession (SSFP) and fast gradient echo (FGRE) cine imaging with 7 mm slice thickness (STH) were used. At 7 T, FGRE with 7 mm and 4 mm STH were applied. End-diastolic volume, end-systolic volume, ejection fraction and mass were calculated.


All 7 T examinations provided excellent blood/myocardium contrast for all slice directions. No significant difference was found regarding ejection fraction and cardiac volumes between SSFP at 1.5 T and FGRE at 7 T, while volumes obtained from FGRE at 1.5 T were underestimated. Cardiac mass derived from FGRE at 1.5 and 7 T was larger than obtained from SSFP at 1.5 T. Agreement of volumes and mass between SSFP at 1.5 T and FGRE improved for FGRE at 7 T when combined with an STH reduction to 4 mm.


This pilot study demonstrates that cardiac chamber quantification at 7 T using FGRE is feasible and agrees closely with SSFP at 1.5 T.


Magnetic resonance imaging Left ventricle Ultrahigh field Cardiac-gated imaging techniques Cine MRI 

Supplementary material

330_2010_1888_MOESM1_ESM.avi (5.6 mb)
Video file 1 Two-chamber view obtained by FGRE cine imaging at 7 T with 4-mm slice thickness underlining the excellent blood/myocardium contrast even in the left ventricular apex (AVI 5764 kb)
330_2010_1888_MOESM2_ESM.avi (5.6 mb)
Video file 2 Short-axis view obtained by FGRE cine imaging at 7 T with 4-mm slice thickness underlining the excellent blood/myocardium contrast and delineation of the left ventricular papillary muscle apparatus and the right ventricular trabeculae (AVI 5764 kb)
330_2010_1888_MOESM3_ESM.avi (5.6 mb)
Video file 3 Four-chamber view by FGRE cine imaging at 7 T with 4-mm slice thickness emphasising the detailed visualisation of right ventricular trabeculae (AVI 5764 kb)
330_2010_1888_MOESM4_ESM.avi (5.6 mb)
Video file 4 Cross-sectional view of the aortic valve including views of the pulmonary and tricuspid valves by FGRE cine imaging at 7 T with 4-mm slice thickness (AVI 5764 kb)


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Copyright information

© European Society of Radiology 2010

Authors and Affiliations

  • Florian von Knobelsdorff-Brenkenhoff
    • 1
    • 2
    • 3
    Email author
  • Tobias Frauenrath
    • 3
  • Marcel Prothmann
    • 2
  • Matthias A. Dieringer
    • 2
    • 3
  • Fabian Hezel
    • 3
  • Wolfgang Renz
    • 3
    • 4
  • Kerstin Kretschel
    • 1
    • 2
  • Thoralf Niendorf
    • 2
    • 3
  • Jeanette Schulz-Menger
    • 1
    • 2
    • 3
  1. 1.Department of Cardiology and NephrologyHELIOS Klinikum Berlin-BuchBerlinGermany
  2. 2.Experimental and Clinical Research Center (ECRC), Working Group on Cardiovascular Magnetic ResonanceMedical University Berlin, Charité Campus BuchBerlinGermany
  3. 3.Berlin Ultrahigh Field FacilityMax Delbrueck Center for Molecular MedicineBerlinGermany
  4. 4.Siemens HealthcareErlangenGermany

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